Molecular structure of Tandospirone hydrochloride, CAS Number: 99095-10-0
Tandospirone hydrochloride (CAS 99095-10-0)
Application:
Tandospirone hydrochloride is a SR-1A partial agonist
CAS Number:
99095-10-0
Purity:
≥98%
Molecular Weight:
419.95
Molecular Formula:
C21H30ClN5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Anxiolytic agent. 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over 5-HT2, 5-HT1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300-41000 nM). Inactive at 5-HT uptake sites, 5-HT1B, β-adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity.
Tandospirone hydrochloride (CAS 99095-10-0) References
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- Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. | Godbout, R., et al. 1991. Neuropharmacology. 30: 679-90. PMID: 1681446
- Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-dopaminergic systems in rats with unilateral 6-hydroxydopamine-generated lesions. | Matsubara, K., et al. 2006. Brain Res. 1112: 126-33. PMID: 16884702
- Paroxetine-induced bruxism effectively treated with tandospirone. | Kishi, Y. 2007. J Neuropsychiatry Clin Neurosci. 19: 90-1. PMID: 17308240
- Tandospirone in the treatment of generalised anxiety disorder and mixed anxiety-depression : results of a comparatively high dosage trial. | Nishitsuji, K., et al. 2004. Clin Drug Investig. 24: 121-6. PMID: 17516698
- Opposite effects of SSRIs and tandospirone in the treatment of REM sleep behavior disorder. | Takahashi, T., et al. 2008. Sleep Med. 9: 317-9. PMID: 17644482
- Involvement of the dorsal hippocampus in mediation of the antianxiety action of tandospirone, a 5-hydroxytryptamine1A agonistic anxiolytic. | Kataoka, Y., et al. 1991. Neuropharmacology. 30: 475-80. PMID: 1865994
- Efficacy of the 5-HT1A agonist tandospirone citrate in improving symptoms of patients with functional dyspepsia: a randomized controlled trial. | Miwa, H., et al. 2009. Am J Gastroenterol. 104: 2779-87. PMID: 19638966
- Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. | Hamik, A., et al. 1990. Biol Psychiatry. 28: 99-109. PMID: 1974152
- Tandospirone suppresses impulsive action by possible blockade of the 5-HT1A receptor. | Ohmura, Y., et al. 2013. J Pharmacol Sci. 122: 84-92. PMID: 23707971
- The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats. | Kasahara, K., et al. 2015. J Pharmacol Sci. 127: 109-16. PMID: 25704026
- Role of tandospirone, a 5-HT1A receptor partial agonist, in the treatment of central nervous system disorders and the underlying mechanisms. | Huang, X., et al. 2017. Oncotarget. 8: 102705-102720. PMID: 29254282
- Neural serotonergic circuits for controlling long-term voluntary alcohol consumption in mice. | Belmer, A., et al. 2022. Mol Psychiatry. 27: 4599-4610. PMID: 36195637
- Effects of K+ channel blockers and openers on antinociception induced by agonists of 5-HT1A receptors. | Robles, LI., et al. 1996. Eur J Pharmacol. 295: 181-8. PMID: 8720582
- Effects of tandospirone on second messenger systems and neurotransmitter release in the rat brain. | Tanaka, H., et al. 1995. Gen Pharmacol. 26: 1765-72. PMID: 8745167
Inhibitor of:
DARPP-32.Activator of:
Serotonin, SR-1A, and SR-5A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tandospirone hydrochloride, 10 mg | sc-204320 | 10 mg | $132.00 | |||
Tandospirone hydrochloride, 50 mg | sc-204320A | 50 mg | $559.00 |