Molecular structure of Valerenic acid, CAS Number: 3569-10-6
Valerenic acid (CAS 3569-10-6)
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Alternate Names:
(2E)-3-[(4S,7R,7aR)-2,4,5,6,7,7a-Hexahydro-3,7-dimethyl-1H-inden-4-yl]-2-methyl-2-propenoic acid
Application:
Valerenic acid is a positive allosteric modulator of the GABAA receptor
CAS Number:
3569-10-6
Purity:
≥98%
Molecular Weight:
234.33
Molecular Formula:
C15H22O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Valerenic acid is a positive allosteric modulator of GABAA receptors that displays preference for beta2 or beta3 subunit receptors. Directly activates the receptor and also blocks the channel at high concentrations. Displays an anxiolytic and sedative activity in vivo. Valerenic acid is an activator of GABA Receptor and SR-5A.
Valerenic acid (CAS 3569-10-6) References
- Valerenic acid derivatives and valepotriates among individuals, varieties and species of Valeriana. | Gao, XQ. and Björk, L. 2000. Fitoterapia. 71: 19-24. PMID: 11449465
- The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. | Yuan, CS., et al. 2004. Anesth Analg. 98: 353-358. PMID: 14742369
- Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. | Dietz, BM., et al. 2005. Brain Res Mol Brain Res. 138: 191-7. PMID: 15921820
- Pharmacokinetics of valerenic acid after administration of valerian in healthy subjects. | Anderson, GD., et al. 2005. Phytother Res. 19: 801-3. PMID: 16220575
- Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid. | Trauner, G., et al. 2008. Planta Med. 74: 19-24. PMID: 18095218
- GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. | Benke, D., et al. 2009. Neuropharmacology. 56: 174-81. PMID: 18602406
- Valerenic acid derivatives as novel subunit-selective GABAA receptor ligands - in vitro and in vivo characterization. | Khom, S., et al. 2010. Br J Pharmacol. 161: 65-78. PMID: 20718740
- Valerian extract characterized by high valerenic acid and low acetoxy valerenic acid contents demonstrates anxiolytic activity. | Felgentreff, F., et al. 2012. Phytomedicine. 19: 1216-22. PMID: 22944521
- The anxiolytic effects of a Valerian extract is based on valerenic acid. | Becker, A., et al. 2014. BMC Complement Altern Med. 14: 267. PMID: 25066015
- Impact of Altitudes and Habitats on Valerenic Acid, Total Phenolics, Flavonoids, Tannins, and Antioxidant Activity of Valeriana jatamansi. | Jugran, AK., et al. 2016. Appl Biochem Biotechnol. 179: 911-26. PMID: 26971960
- De novo synthesis of the sedative valerenic acid in Saccharomyces cerevisiae. | Wong, J., et al. 2018. Metab Eng. 47: 94-101. PMID: 29545148
- The roles of valerenic acid on BDNF expression in the SH-SY5Y cell. | Gonulalan, EM., et al. 2018. Saudi Pharm J. 26: 960-964. PMID: 30416353
- Seasonal variation of the essential oil, valerenic acid and derivatives, and velopotriates in Valeriana officinalis roots and rhizomes, and the selection of plants suitable for phytomedicines. | Bos, R., et al. 1998. Planta Med. 64: 143-7. PMID: 9556440
Activator of:
GABA Receptor, and SR-5A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Valerenic acid, 1 mg | sc-204377 | 1 mg | $71.00 | |||
Valerenic acid, 10 mg | sc-204377A | 10 mg | $474.00 |