SPT3 Inhibitors
SPT3 Inhibitors primarily function to modulate the intricate mechanisms of transcriptional regulation, in which SPT3 plays a pivotal role as a member of the SAGA complex. The prominence of histone acetylation and deacetylation in transcriptional activation and repression necessitates the involvement of HDAC inhibitors like Trichostatin A, Vorinostat, and Nicotinamide. These molecules aim to increase global histone acetylation, subsequently influencing the myriad processes in which SPT3 and its associated SAGA complex partake.
Similarly, the role of histone acetyltransferases (HATs) cannot be sidelined, considering SPT3's involvement in histone acetylation. Anacardic acid, Garcinol, and Curcumin, known to inhibit HATs like p300/CBP, indirectly provide a mechanism to modulate SPT3's function. On a broader spectrum, molecules like ICG-001, PU139, and JQ1 target other components of the transcriptional machinery, further highlighting the intricate nature of transcriptional regulation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Histone deacetylase (HDAC) inhibitor that increases histone acetylation levels. This could indirectly impact SPT3's function within SAGA. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
HDAC inhibitor known to increase global histone acetylation, potentially modulating processes where SPT3 is active. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Inhibits histone acetyltransferase (HAT) p300/CBP. SPT3's role in acetylation could be influenced if p300/CBP is involved. | ||||||
Garcinol | 78824-30-3 | sc-200891 sc-200891A | 10 mg 50 mg | $124.00 $502.00 | 13 | |
HAT inhibitor affecting p300/CBP. By modulating HAT activity, it can indirectly influence SPT3's acetylation function. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Sirtuin HDAC inhibitor. This can increase histone acetylation, potentially affecting pathways where SPT3 plays a role. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Inhibits p300/CBP HAT activity. SPT3's role in SAGA-mediated acetylation might be influenced if p300/CBP has any associated function. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
Inhibits BRD4 bromodomain. Affecting BRD4's role in transcription elongation may indirectly modulate SPT3-associated processes. | ||||||
DBeQ | 177355-84-9 | sc-499943 | 10 mg | $330.00 | 1 | |
VCP/p97 inhibitor. Involved in chromatin-associated degradation, which might indirectly touch upon SPT3's regulatory roles. | ||||||
Tenovin-6 | 1011557-82-6 | sc-224296 sc-224296A | 1 mg 5 mg | $272.00 $1214.00 | 9 | |
Sirtuin inhibitor, affecting HDAC activity. Increased histone acetylation may indirectly affect processes where SPT3 is involved. | ||||||