Sprr2a2 Activators
Chemical activators of Sprr2a2 include a variety of naturally occurring compounds that engage specific cellular signaling pathways, resulting in the functional activation of this protein. Resveratrol, for instance, can activate the Sirtuin pathway, known for its role in deacetylating proteins, thereby possibly increasing the functional efficiency of Sprr2a2. Curcumin and sulforaphane both activate the Nrf2 pathway, which is integral to the cellular defense against oxidative stress, implying an enhancement of Sprr2a2's role in this protective response. Similarly, quercetin's activation of the PI3K/Akt signaling pathway can lead to transcriptional events that augment Sprr2a2 activity, associated with cell survival and stress responses. Moreover, epigallocatechin gallate's interaction with the 67-kDa laminin receptor can trigger a cascade of cellular signaling that potentially amplifies the activity of Sprr2a2 within the cellular matrix.
Continuing with the role of chemical activators, genistein's modulation of estrogen receptor-related pathways can influence the activity of Sprr2a2, implicating it in the cellular stress response. Capsaicin, through its activation of the TRPV1 receptor, can lead to a rise in intracellular calcium levels, which might trigger pathways that elevate Sprr2a2 function in response to environmental stressors. Caffeic acid phenethyl ester, by initiating the NF-kB pathway, is involved in stress and inflammation responses, which could functionally activate Sprr2a2. Additionally, kaempferol-mediated AMPK pathway activation and indole-3-carbinol's modulation of the AhR receptor pathway could also enhance the activity of Sprr2a2. Alpha-lipoic acid might activate signaling pathways related to the cellular stress response, thus influencing Sprr2a2 activity. Finally, zinc pyrithione's engagement with MAPK signaling pathways, which are associated with cell proliferation and stress response, can lead to the functional activation of Sprr2a2, a protein involved in epidermal differentiation and barrier formation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can activate the Sirtuin pathway, which is involved in the regulation of proteins by deacetylation. Sirtuins can activate Sprr2a2 by deacetylating lysine residues, potentially enhancing its function in the cellular stress response and cornification. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can activate the Nrf2 pathway, leading to the upregulation of cytoprotective proteins. As Sprr2a2 is involved in cellular defense, the activation of Nrf2 can result in increased functional activity of Sprr2a2 in response to oxidative stress. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates the Nrf2 signaling pathway, which can lead to the functional activation of antioxidant response element (ARE) driven genes, including Sprr2a2, enhancing its activity in the context of cellular protection from oxidative damage. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin activates the PI3K/Akt signaling pathway, which can lead to the activation of transcription factors that promote the activity of proteins such as Sprr2a2, involved in cell survival and stress responses. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate can activate the 67-kDa laminin receptor, which is implicated in cellular signaling related to stress and survival pathways. This activation can lead to downstream effects that enhance the activity of Sprr2a2 in the cellular matrix. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein activates the estrogen receptor-related pathways, which can modulate the activity of various proteins involved in cellular signaling. Through this activation, it can lead to the downstream activation of Sprr2a2's role in cellular stress responses. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates the TRPV1 receptor, which can lead to an increase in intracellular calcium, triggering cascades that activate proteins such as Sprr2a2, which plays a role in the response to environmental stressors like heat and inflammation. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $70.00 $290.00 $600.00 | 19 | |
Caffeic acid phenethyl ester activates the NF-kB pathway, which is involved in the response to stress and inflammation. The activation of NF-kB can lead to the functional activation of Sprr2a2, which is implicated in cellular protective mechanisms. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $97.00 $212.00 $500.00 | 11 | |
Kaempferol activates the AMPK pathway, which can influence the activity of proteins involved in cellular stress responses. Through AMPK activation, Sprr2a2 can be functionally activated to play its role in cell survival and stress signaling. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $38.00 $60.00 $143.00 $306.00 $1012.00 | 5 | |
Indole-3-carbinol can modulate the AhR receptor pathway, which is involved in xenobiotic metabolism. Activation of AhR can lead to the activation of signaling pathways that may enhance the functional activity of Sprr2a2. | ||||||