SPRED2 Activators
SPRED2 activators encompass a range of chemical compounds that can either directly enhance the functional activity of SPRED2 or indirectly trigger signaling events leading to its activation. These compounds operate primarily via the cAMP-dependent protein kinase (PKA) pathway, a signaling cascade that SPRED2 is known to interact with. Forskolin, Isoproterenol, Rolipram, IBMX, Epinephrine, Norepinephrine, PGE2, Papaverine, Dobutamine, and Terbutaline enhance the functional activity of SPRED2 by increasing intracellular cAMP levels, which in turn can activate PKA. PKA is known to phosphorylate and activate SPRED2.
In contrast, H-89 and SQ 22536 can lead to a decrease in the phosphorylation of SPRED2 due to their inhibitory effects on PKA and adenylate cyclase, respectively. However, this decrease in phosphorylation can trigger a negative feedback loop, activating Ras signaling, which can subsequently activate SPRED2. This illustrates the complex interplay of regulatory mechanisms in cellular signaling pathways. Although these compounds have inhibitory effects on certain enzymes or pathways, they can indirectly enhance the functional activity of SPRED2 by triggering these feedback mechanisms. These diverse compounds, by acting on different components of the same pathway, collectively contribute to the functional activation of SPRED2.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, leading to increased levels of cyclic AMP (cAMP). Higher cAMP levels can trigger the cAMP-dependent protein kinase (PKA) pathway, which is known to phosphorylate and activate SPRED2. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic receptor agonist. Activation of these receptors increases intracellular cAMP, which can stimulate PKA. PKA phosphorylates and activates SPRED2. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a potent inhibitor of phosphodiesterase 4 (PDE4), which results in an increase in cAMP levels. By increasing cAMP, rolipram triggers PKA, which can phosphorylate and activate SPRED2. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, raising cellular cAMP levels. Increased cAMP triggers PKA, which in turn phosphorylates and activates SPRED2. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine is a hormone that activates beta-adrenergic receptors. This receptor activation increases cAMP levels, which can stimulate PKA. PKA phosphorylates and activates SPRED2. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
Norepinephrine is a hormone that activates beta-adrenergic receptors. This receptor activation increases cAMP levels, which can stimulate PKA. PKA phosphorylates and activates SPRED2. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 is a prostaglandin that stimulates adenylate cyclase to increase cAMP levels. The resulting cAMP accumulation triggers PKA, which phosphorylates and activates SPRED2. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $95.00 $363.00 | 13 | |
SQ 22536 is an adenylate cyclase inhibitor. The inhibition of adenylate cyclase reduces cAMP levels, which decreases PKA activity. This decrease in PKA activity can trigger a negative feedback loop, activating Ras signaling and subsequently activating SPRED2. | ||||||
Papaverine | 58-74-2 | sc-279951 sc-279951A sc-279951B | 10 mg 50 mg 100 mg | $153.00 $265.00 $459.00 | ||
Papaverine is a PDE inhibitor that raises cellular cAMP levels. Higher cAMP levels trigger PKA, which phosphorylates and activates SPRED2. | ||||||
Dobutamine | 34368-04-2 | sc-507555 | 100 mg | $295.00 | ||
Dobutamine is a beta-1 adrenergic receptor agonist that can increase cAMP levels, which in turn stimulate PKA. PKA phosphorylates and in turn activates SPRED2. | ||||||