SPINK3 Inhibitors
SPINK3 inhibitors encompass a variety of chemicals that target different proteases or cellular processes SPINK3 is involved in, effectively decreasing the demand for SPINK3's protease inhibitory function. For instance, Amiloride, a diuretic acting as an inhibitor of epithelial sodium channels, indirectly lessens the functional necessity of SPINK3 by targeting the channels that SPINK3 helps to regulate. Similarly, Aprotinin and AEBSF, both serine protease inhibitors, preempt the need for SPINK3's activity by inhibiting the proteases SPINK3 naturally regulates. These compounds, along with Benzamidine and Gabexate Mesilate, demonstrate how the inhibition of serine proteases can diminish the need for SPINK3's protective role against protease-mediated damage. This indirect inhibition is a key mechanism by which SPINK3 inhibitors operate, ensuring the protein's activity is reduced by limiting its target enzymes' activity.
Additional inhibitors like Nafamostat, Camostat Mesilate, and Marimastat serve to further illustrate this point by targeting different classes of proteases, thereby lessening SPINK3's functional requirements across various biochemical pathways. Tranexamic Acid, through its antifibrinolytic properties, inhibits the conversion of plasminogen to plasmin, which in turn indirectly limits SPINK3's role in modulating protease activity. E-64 and Leupeptin, targeting cysteine and thiol proteases respectively, operate under a similar paradigm by reducing protease activity and thereby decreasing the demand for SPINK3's regulatory influence.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
This diuretic acts as a direct inhibitor of epithelial sodium channels (ENaC). Since SPINK3 is implicated in modulating protease activity that can regulate ENaC, amiloride would indirectly reduce the functional necessity of SPINK3 by inhibiting the target it helps to regulate. | ||||||
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | $110.00 $400.00 $1615.00 | 51 | |
A serine protease inhibitor that can prevent the activation of various proteases. SPINK3 functions to inhibit protease activity, so the presence of aprotinin would reduce the need for SPINK3's protective role, thus indirectly inhibiting its functional activity. | ||||||
Benzamidine | 618-39-3 | sc-233933 | 10 g | $286.00 | 1 | |
A reversible inhibitor of serine proteases, by reducing protease activity, benzamidine would decrease the functional requirement for SPINK3's inhibitory action. | ||||||
Gabexate mesylate | 56974-61-9 | sc-215066 | 5 mg | $100.00 | ||
This serine protease inhibitor used for pancreatitis could diminish the activity of proteases, which are the natural targets of SPINK3, thereby indirectly reducing the functional demand for SPINK3. | ||||||
Camostat mesylate | 59721-29-8 | sc-203867 sc-203867A sc-203867B sc-203867C sc-203867D sc-203867E | 10 mg 50 mg 500 mg 1 g 10 g 100 g | $42.00 $179.00 $306.00 $612.00 $2040.00 $4386.00 | 5 | |
Another serine protease inhibitor that would decrease protease activity, thereby reducing the role of SPINK3 in inhibiting these enzymes. | ||||||
Tranexamic acid | 1197-18-8 | sc-204921 sc-204921A | 5 g 10 g | $28.00 $49.00 | 10 | |
An antifibrinolytic that inhibits the activation of plasminogen to plasmin, a molecule involved in the degradation of fibrin clots. By inhibiting plasmin, the role of SPINK3 in protease inhibition is indirectly reduced as there is less protease activity to regulate. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
This irreversible inhibitor of cysteine proteases would reduce the activity of certain proteases, thereby diminishing the functional necessity for SPINK3's inhibitory role on these enzymes. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $165.00 $214.00 $396.00 $617.00 $4804.00 | 19 | |
As a broad-spectrum metalloprotease inhibitor, marimastat would indirectly inhibit SPINK3 by reducing the protease activity that SPINK3 is known to regulate. | ||||||
AEBSF hydrochloride | 30827-99-7 | sc-202041 sc-202041A sc-202041B sc-202041C sc-202041D sc-202041E | 50 mg 100 mg 5 g 10 g 25 g 100 g | $50.00 $120.00 $420.00 $834.00 $1836.00 $4896.00 | 33 | |
This serine protease inhibitor would decrease the functional demand for SPINK3 by inhibiting the activity of the proteases that SPINK3 regulates. | ||||||