SPINK14 Inhibitors
Inhibitors of Serine peptidase inhibitor Kazal type 14 (SPINK14) encompass various chemical entities that exert their effects on the activity of this protein by modulating the protease landscape within the cellular environment. The mode of action of these compounds involves competitive inhibition with SPINK14 for binding to serine proteases, which are the primary targets of SPINK14, effectively reducing the protein's ability to interact with these enzymes. By occupying the active sites on serine proteases, these inhibitors negate the functional necessity of SPINK14, as they mimic or surpass the native inhibition SPINK14 provides. This competition for serine protease binding sites not only decreases the biological demand for SPINK14's activity but also may lead to a reduction in the protein's expression due to a negative feedback mechanism inherent in the protease-inhibitor regulation system.
Moreover, certain inhibitors, although they do not directly target serine proteases, have an indirect impact on SPINK14's functionality. These inhibitors affect the overall proteolytic activity within the cell by inhibiting other types of proteases, such as cysteine and aspartyl proteases, which can lead to a compensatory decrease in serine protease activity. The resulting alteration in the cellular protease balance may inadvertently diminish the need for SPINK14's regulatory action, effectively reducing its role in inhibiting serine proteases.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzamidine | 618-39-3 | sc-233933 | 10 g | $286.00 | 1 | |
Acts as a reversible inhibitor of many trypsin-like serine proteases. By inhibiting these proteases, SPINK14's regulatory role is diminished since there is a decreased demand for its inhibitory function. | ||||||
Nafamostat mesylate | 82956-11-4 | sc-201307 sc-201307A | 10 mg 50 mg | $80.00 $300.00 | 4 | |
It is a synthetic serine protease inhibitor that would compete with SPINK14 for binding to proteases, thereby diminishing SPINK14's ability to interact with its target enzymes. | ||||||
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | $110.00 $400.00 $1615.00 | 51 | |
A potent inhibitor of several serine proteases. Its mechanism of action would lead to reduced functional necessity for SPINK14 since it would already be inhibiting the same proteases that SPINK14 might inhibit. | ||||||
Gabexate mesylate | 56974-61-9 | sc-215066 | 5 mg | $100.00 | ||
This chemical is an inhibitor of various serine proteases, potentially reducing the functional requirement for SPINK14's activity by directly competing for the same enzymes. | ||||||
Chymostatin | 9076-44-2 | sc-202541 sc-202541A sc-202541B sc-202541C sc-202541D | 5 mg 10 mg 25 mg 50 mg 100 mg | $153.00 $255.00 $627.00 $1163.00 $2225.00 | 3 | |
Chymostatin is an inhibitor of chymotrypsin-like serine proteases. If SPINK14 is involved in inhibiting these proteases, chymostatin would lower the demand for SPINK14 activity by inhibiting its target enzymes. | ||||||
AEBSF hydrochloride | 30827-99-7 | sc-202041 sc-202041A sc-202041B sc-202041C sc-202041D sc-202041E | 50 mg 100 mg 5 g 10 g 25 g 100 g | $50.00 $120.00 $420.00 $834.00 $1836.00 $4896.00 | 33 | |
A serine protease inhibitor that irreversibly binds to the active site of the enzyme, thereby reducing the need for SPINK14's inhibitory action on these enzymes. | ||||||
Camostat mesylate | 59721-29-8 | sc-203867 sc-203867A sc-203867B sc-203867C sc-203867D sc-203867E | 10 mg 50 mg 500 mg 1 g 10 g 100 g | $42.00 $179.00 $306.00 $612.00 $2040.00 $4386.00 | 5 | |
As a synthetic serine protease inhibitor, it would compete with SPINK14 for the same target proteases, possibly decreasing the physiological role of SPINK14. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $72.00 $145.00 $265.00 $489.00 $1399.00 $99.00 | 19 | |
A chemical that inhibits serine and cysteine proteases; the inhibition of serine proteases would compete with SPINK14's function, reducing its activity. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
This is an inhibitor of cysteine proteases. As SPINK14 is implicated in serine protease inhibition, E-64 would not compete directly but could indirectly reduce SPINK14 activity by altering protease activity balance within the cell. | ||||||