SPATS2L Activators
Chemical activators of SPATS2L utilize various intracellular signaling pathways to modulate its activity through phosphorylation, a process vital for the regulation of protein function. Dibutyryl-cAMP and Forskolin increase the levels of cyclic AMP (cAMP) within the cell, which in turn activates protein kinase A (PKA). This kinase is known for phosphorylating numerous substrates, including SPATS2L, thereby modifying its activity. Ionomycin and A23187, both calcium ionophores, elevate intracellular calcium concentrations. This surge in calcium ions can activate calcium-dependent protein kinases, which have the capacity to phosphorylate SPATS2L. Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), a family of kinases that phosphorylate a wide array of proteins. PKC activation often results in the phosphorylation of proteins like SPATS2L, impacting its activity.
Furthermore, the inhibition of protein phosphatases by compounds such as Okadaic Acid and Calyculin A leads to an increase in the phosphorylated state of cellular proteins. This inhibition prevents the dephosphorylation and inactivation of proteins, thereby sustaining the active phosphorylated form of SPATS2L. Anisomycin activates stress-activated protein kinases, which may subsequently phosphorylate SPATS2L as part of the cellular response to stress. Epigallocatechin gallate (EGCG) modulates various kinases and phosphatases, altering the phosphorylation landscape within the cell, which can affect the activation state of SPATS2L. Bryostatin 1, as a modulator of PKC, influences the phosphorylation profile of SPATS2L. Sphingosine 1-phosphate, through its interaction with specific receptors, initiates signaling cascades that can culminate in the phosphorylation and consequent activation of SPATS2L. Lastly, Piceatannol inhibits Syk kinase, leading to alterations in downstream signaling pathways that can result in the phosphorylation and regulation of SPATS2L activity by other kinases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP, a cell-permeable cAMP analog, can activate cAMP-dependent protein kinase A (PKA). PKA activation leads to phosphorylation of downstream targets, which can enhance the activation of SPATS2L involved in RNA processing. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, activating calcium-dependent protein kinases. These kinases can then phosphorylate and activate SPATS2L, which is sensitive to calcium-mediated signaling. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing intracellular cAMP levels and thereby activating PKA. PKA then phosphorylates substrates including SPATS2L, resulting in its functional activation related to mRNA metabolism. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which phosphorylates a wide range of cellular proteins. PKC-mediated phosphorylation pathways can lead to the activation of SPATS2L, which may be regulated by PKC signaling. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is an inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels within the cell. By preventing dephosphorylation, it ensures the continued activation of SPATS2L through its phosphorylated state. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Similar to okadaic acid, Calyculin A inhibits protein phosphatases, thereby maintaining proteins in their phosphorylated and active states. This could support the sustained activation of SPATS2L. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is an activator of stress-activated protein kinases which could lead to the phosphorylation and activation of SPATS2L as part of the cellular stress response. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a known modulator of various cell signaling pathways, can influence kinases and phosphatases involved in the phosphorylation state of proteins. This could lead to the activation of SPATS2L through alterations in its phosphorylation status. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $240.00 | 9 | |
Bryostatin 1 is a potent modulator of PKC which may result in altered phosphorylation and activation of SPATS2L, assuming SPATS2L is a substrate for PKC or is influenced by PKC-regulated pathways. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine 1-phosphate is a bioactive lipid that activates sphingosine 1-phosphate receptors, triggering signaling cascades that can lead to the phosphorylation and activation of proteins including SPATS2L. | ||||||