SPANX-A-E Activators
The SPANX-A-E genes, part of the SPANX (Sperm Protein Associated with the Nucleus, X chromosome) family, encode a group of proteins that are primarily expressed in human testicular tissue and are associated with sperm development. This family includes several closely related members, namely SPANX-A, SPANX-B, SPANX-C, SPANX-D, and SPANX-E, each encoded by distinct but related genes located on the X chromosome.
The SPANX proteins are known for their role in spermatogenesis, the process of sperm cell development. They are mainly expressed in post-meiotic spermatids, suggesting a role in the later stages of sperm maturation. These proteins are thought to be involved in the restructuring of chromatin and nuclear shaping that occurs during the transformation of spermatids into mature spermatozoa. Such restructuring is crucial for the proper packaging of DNA in sperm heads, which is essential for successful fertilization.In addition to their role in testicular tissue, SPANX proteins have gained attention for their expression in various types of cancer, particularly melanoma and carcinomas of the prostate, breast, and lung. Their presence in malignant cells and their absence in normal somatic cells make them candidates for cancer biomarkers and targets for cancer immunotherapy.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid is crucial in spermatogenesis and might influence the expression of SPANX proteins. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil, a chemotherapeutic agent, can impact cancer cell proliferation, potentially affecting SPANX protein expression. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel, an anti-cancer drug, affects microtubule dynamics and might impact cells expressing SPANX proteins. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin, used in cancer therapy, could potentially influence SPANX protein expression in cancer cells. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin is a chemotherapy agent in research that could affect the expression or function of SPANX proteins in cancer cells. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol, while primarily a female hormone, can have effects on spermatogenesis and potentially influence SPANX expression. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $272.00 | 18 | |
Tamoxifen, used in breast cancer treatment, could potentially affect the expression of SPANX proteins in certain cancer cells. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Folic Acid is essential for cell growth and replication, potentially influencing SPANX protein expression. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate, used in chemotherapy, might affect the expression or function of SPANX proteins in certain cancer contexts. | ||||||