SPANX-5 Inhibitors
SPANX-5 inhibitors belong to a specialized category of chemical agents designed to interact with the SPANX family of proteins, where SPANX-5 is a specific target within this group. The SPANX (Sperm Protein Associated with the Nucleus on the X chromosome) proteins are encoded by genes that are predominantly expressed in human reproductive tissues. They are known to be involved in various cellular processes due to their localization in the nucleus and their potential role in the regulation of gene expression. SPANX-5 inhibitors are developed to modulate the activity of the SPANX-5 protein by binding to it and altering its function. The inhibition of SPANX-5 by these compounds can affect the protein's normal behavior and interactions within the cellular environment.
To understand the significance of SPANX-5 inhibitors, it is essential to consider the broader context of protein inhibition in cellular biochemistry. Inhibitors are molecules that can prevent the action of proteins by binding to them, which can result in changes to the protein's conformation, the blockage of active sites, or the disruption of interaction with other molecular partners. In the case of SPANX-5, inhibitors are designed to specifically target and bind to this protein, thereby impacting its role in the cell. The exact mechanism of inhibition depends on the molecular structure of the inhibitor and its affinity for the SPANX-5 protein. Researchers developing SPANX-5 inhibitors must take into account the delicate balance required to ensure specificity and effectiveness of the inhibitor, as well as the need to minimize any off-target effects that could impact other cellular proteins. The design and synthesis of these inhibitors require a deep understanding of the molecular structure of SPANX-5 and the dynamics of its interaction with potential inhibitory compounds.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
YM 155 | 781661-94-7 | sc-364661 sc-364661A | 5 mg 25 mg | $129.00 $497.00 | 3 | |
YM155 is known as a survivin suppressant, which downregulates the inhibitor of apoptosis proteins (IAP). Since SPANX-5 is associated with cancer testis antigens and is implicated in mechanisms of cell death and survival, the suppression of survivin by YM155 can lead to an overall pro-apoptotic environment, thereby reducing the functional activity of SPANX-5. | ||||||
AZD1152-HQPA | 722544-51-6 | sc-265334 | 10 mg | $375.00 | ||
AZD1152-HQPA is an Aurora B kinase inhibitor that disrupts mitotic spindle assembly and chromosome alignment. SPANX-5 plays a role in sperm cell development, which includes processes of cell division. Inhibiting Aurora B kinase can indirectly affect SPANX-5 by disrupting the cell cycle in spermatogenic cells. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and inhibits their disassembly, leading to cell cycle arrest in the G2/M phase. Given that SPANX-5 is involved in the reproductive system, the disruption of cell division by paclitaxel can affect SPANX-5’s role in spermatogenesis. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that leads to the accumulation of proteins destined for degradation, which can trigger apoptosis. Because SPANX-5 is related to cancer and immune evasion, inhibiting the proteasome can decrease the survival of cells expressing SPANX-5, leading to its functional inhibition. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram inhibits aldehyde dehydrogenase (ALDH), an enzyme involved in alcohol metabolism and cell survival. By inhibiting ALDH, disulfiram could affect cellular environments where SPANX-5 is expressed, particularly in testicular cancer cells, impacting the cell's survival mechanisms. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Nutlin-3 disrupts the interaction between p53 and MDM2, leading to the activation of p53 and induction of apoptosis. As SPANX-5 is implicated in the evasion of immune surveillance in cancer, the restoration of p53 function can counteract the survival of cells expressing SPANX-5. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that impedes the MAPK/ERK signaling pathway, which is involved in cell proliferation and survival. By inhibiting this pathway, PD98059 can influence cellular processes where SPANX-5 might be implicated, particularly in cancer cells, leading to decreased SPANX-5 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that blocks the AKT signaling pathway, a key pathway in cell survival and proliferation. SPANX-5, being associated with cell survival, particularly in testicular cells, can be indirectly inhibited by the action of LY294002 on PI3K/AKT pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that interferes with cell growth and proliferation. Since SPANX-5 is expressed in reproductive tissues, the inhibition of mTOR signaling can indirectly affect the function of SPANX-5 in cell survival and proliferation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to increased cytosolic calcium and can induce ER stress-induced apoptosis. This can affect cells expressing SPANX-5 by disrupting calcium homeostasis and promoting conditions that are unfavorable for SPANX-5’s activity. | ||||||