Molecular structure of YM 155, CAS Number: 781661-94-7
YM 155 (CAS 781661-94-7)
See product citations (3)
Alternate Names:
1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-, bromide
Application:
YM 155 is an inhibitor of survivin expression and apoptosis inducer
CAS Number:
781661-94-7
Purity:
>96%
Molecular Weight:
443.29
Molecular Formula:
C20H19BrN4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
YM 155 is a small molecule inhibitor that functions by targeting and inhibiting the activity of the survivin protein. Ym 155 disrupts the function of survivin by binding to its active site, thereby preventing its interaction with other cellular components. By doing so, YM 155 interferes with the regulation of cell division and apoptosis, ultimately leading to the inhibition of cancer cell growth and proliferation. YM 155 may induce apoptosis in cancer cells by downregulating the expression of survivin.
YM 155 (CAS 781661-94-7) References
- Survivin inhibition is critical for Bcl-2 inhibitor-induced apoptosis in hepatocellular carcinoma cells. | Zhao, X., et al. 2011. PLoS One. 6: e21980. PMID: 21829603
- YM-155 potentiates the effect of ABT-737 in malignant human glioma cells via survivin and Mcl-1 downregulation in an EGFR-dependent context. | Jane, EP., et al. 2013. Mol Cancer Ther. 12: 326-38. PMID: 23325792
- Survivin inhibitor YM-155 sensitizes tumor necrosis factor- related apoptosis-inducing ligand-resistant glioma cells to apoptosis through Mcl-1 downregulation and by engaging the mitochondrial death pathway. | Premkumar, DR., et al. 2013. J Pharmacol Exp Ther. 346: 201-10. PMID: 23740602
- ABT-199, a BH3 mimetic that specifically targets Bcl-2, enhances the antitumor activity of chemotherapy, bortezomib and JQ1 in 'double hit' lymphoma cells. | Johnson-Farley, N., et al. 2015. Leuk Lymphoma. 56: 2146-52. PMID: 25373508
- A combination of YM-155, a small molecule survivin inhibitor, and IL-2 potently suppresses renal cell carcinoma in murine model. | Guo, K., et al. 2015. Oncotarget. 6: 21137-47. PMID: 26023798
- Sensitivity of chronic lymphocytic leukemia cells to small targeted therapeutic molecules: An in vitro comparative study. | Sylvan, SE., et al. 2016. Exp Hematol. 44: 38-49.e1. PMID: 26325331
- A Novel Combination Treatment Targeting BCL-XL and MCL1 for KRAS/BRAF-mutated and BCL2L1-amplified Colorectal Cancers. | Cho, SY., et al. 2017. Mol Cancer Ther. 16: 2178-2190. PMID: 28611106
- Survivin in Insulin-Like Growth Factor-Induced Resistance to Lapatinib in Head and Neck Squamous Carcinoma Cells. | Lehman, CE., et al. 2019. Front Oncol. 9: 13. PMID: 30729097
- MS-275 potentiates the effect of YM-155 in lung adenocarcinoma via survivin downregulation induced by miR-138 and miR-195. | Luo, BL., et al. 2019. Thorac Cancer. 10: 1355-1368. PMID: 31090206
- Restoring apoptosis dysregulation using survivin inhibitor in nasopharyngeal cancer. | Shi, J., et al. 2020. Head Neck. 42: 913-923. PMID: 31925995
- Selection of Effective Therapies Using Three-Dimensional in vitro Modeling of Chondrosarcoma. | Palubeckaitė, I., et al. 2020. Front Mol Biosci. 7: 566291. PMID: 33425984
- Clinical application of a lung cancer organoid (tumoroid) culture system. | Yokota, E., et al. 2021. NPJ Precis Oncol. 5: 29. PMID: 33846488
- Dehydroabietic Acid Is a Novel Survivin Inhibitor for Gastric Cancer. | Kim, WJ., et al. 2021. Plants (Basel). 10: PMID: 34067279
- Regulation of survivin and caspase/Bcl-2/Cyto-C signaling by TDB-6 induces apoptosis of colorectal carcinoma LoVo cells. | Shi, X., et al. 2022. J Gastrointest Oncol. 13: 2322-2332. PMID: 36388656
- IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression. | Hagemann, S., et al. 2023. Mol Cancer. 22: 88. PMID: 37246217
Inhibitor of:
4921511H03Rik, BID, BNIP-2, BNIP-3, c-IAP 1, dcTRAILR2, DDX25, DRP2, EXOSC2, GAGE12C, HAX-1, Mnt, PIWI, RNase III Drosha, SPANX-5, Survivin, Tankyrase, Transcription Factor, and XIAP.Activator of:
MCAF2, and p73.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
YM 155, 5 mg | sc-364661 | 5 mg | $132.00 | |||
YM 155, 25 mg | sc-364661A | 25 mg | $507.00 |