SP140 Activators
SP140, also known as Nuclear Body Protein SP140, is a protein that is highly expressed in immune cells, particularly in lymphoid tissues. It belongs to a family of nuclear body proteins that include SP100, SP110, and SP140L, characterized by a shared domain structure that suggests roles in chromatin organization and transcriptional regulation. The SP140 protein contains several domains indicative of its involvement in chromatin-mediated gene regulation: a plant homeodomain (PHD) finger, a bromodomain, a SAND domain, and a Leucine-rich repeat (LRR).
The PHD finger and bromodomain are known to be important for binding to histones and reading epigenetic marks, which is essential for the regulation of gene expression. The SAND domain is implicated in DNA binding, whereas LRRs typically participate in protein-protein interactions. SP140 has been implicated in the pathogenesis of chronic lymphocytic leukemia and is associated with autoimmune diseases like multiple sclerosis. This association is likely due to its role in the regulation of genes involved in immune response and inflammation.Alterations in the SP140 gene can affect its expression and function, leading to dysregulation of immune-related genes and contributing to disease.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to modulate inflammatory pathways, which might influence SP140 expression in immune cells. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has anti-inflammatory properties and can modulate the expression of genes involved in immune responses. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane affects the NF-κB pathway, which is integral to immune response and could induce SP140 expression. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic acid has been shown to influence signaling pathways in immune cells, potentially affecting SP140 expression. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 regulates gene expression via the vitamin D receptor, which could impact SP140 expression in leukocytes. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc gluconate influences immune function and may play a role in the regulation of genes like SP140. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $41.00 | 4 | |
Aspirin modulates inflammatory pathways and could potentially increase the expression of immune-related proteins like SP140. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate is used in immune disorders and might affect SP140 expression through its anti-inflammatory effects. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Azacytidine can cause demethylation of DNA, potentially leading to the activation of genes including SP140. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid, an HDAC inhibitor, might enhance SP140 expression by altering chromatin structure. | ||||||