Date published: 2025-10-4

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Sox-6 Inhibitors

Sox-6 inhibitors belong to a specific chemical class of compounds designed to modulate the activity of the Sox-6 transcription factor. Sox-6 is a member of the Sox (SRY-related HMG box) family of transcription factors, which play essential roles in the regulation of gene expression during various cellular processes. These inhibitors are designed to specifically target Sox-6 and interfere with its function, thereby affecting downstream gene expression pathways. By selectively inhibiting the activity of Sox-6, these compounds may have the potential to alter cellular responses and physiological processes associated with Sox-6 dysregulation.

The mechanism of action of Sox-6 inhibitors typically involves direct interaction with Sox-6 or its co-regulators, influencing the binding of Sox-6 to its target genes or interfering with its transcriptional activation function. Research into Sox-6 inhibitors is ongoing, with scientists exploring the structural characteristics and molecular interactions necessary to develop potent and selective compounds. Understanding the specific roles of Sox-6 in different cellular contexts and its involvement in disease processes may provide valuable insights for potential future applications of these inhibitors in various fields of research.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Celastrol, Celastrus scandens

34157-83-0sc-202534
10 mg
$155.00
6
(1)

Celastrol is known for its anti-inflammatory and antioxidant properties. It has been studied for its potential to impede Sox-6 and its role in conditions related to Sox-6 dysregulation.

Ro 31-8220

138489-18-6sc-200619
sc-200619A
1 mg
5 mg
$90.00
$240.00
17
(1)

This is a chemical compound belonging to the family of bisindolylmaleimides. It has shown inhibitory effects on various protein kinases, including Sox-6.

SB 431542

301836-41-9sc-204265
sc-204265A
sc-204265B
1 mg
10 mg
25 mg
$80.00
$212.00
$408.00
48
(1)

SB431542 is a selective inhibitor of transforming growth factor-beta (TGF-beta) type I receptor (ALK5), which is implicated in Sox-6 regulation.

Dorsomorphin dihydrochloride

1219168-18-9sc-361173
sc-361173A
10 mg
50 mg
$182.00
$736.00
28
(2)

Also known as Compound C, dorsomorphin is an AMP-activated protein kinase (AMPK) inhibitor that has been shown to inhibit Sox-6 expression indirectly through the TGF-beta pathway.

ALK5 Inhibitor II

446859-33-2sc-221234
sc-221234A
sc-221234B
sc-221234C
sc-221234D
sc-221234E
sc-221234F
1 mg
5 mg
10 mg
50 mg
100 mg
500 mg
1 g
$75.00
$150.00
$215.00
$650.00
$1224.00
$4296.00
$7818.00
8
(1)

Repsox is another TGF-beta type I receptor (ALK5) inhibitor that has demonstrated the ability to regulate Sox-6 expression.

Hesperadin

422513-13-1sc-490384
10 mg
$304.00
(0)

Hesperadin is an inhibitor of Aurora B kinase, and it has been reported to modulate Sox-6 expression in certain cellular contexts.

Lys05

1391426-24-6sc-507532
5 mg
$140.00
(0)

Lys05 is a lysosome-targeting agent that has been investigated for its potential to inhibit Sox-6 in certain pathological conditions.

SRPIN 340

218156-96-8sc-394310
10 mg
$222.00
1
(1)

SRPIN340 is a serine/arginine-rich protein kinase (SRPK) inhibitor, and it has been associated with the regulation of Sox-6 splicing.