Sos 2 Activators
Sos 2 Activators form a diverse group of compounds that intricately modulate cellular signaling pathways to influence the activation of the Sos 2 protein. These pathways, including MAPK/ERK, PI3K/Akt, and calcium-dependent signaling, are crucial in regulating cellular responses. A notable member of this chemical class is U0126, a MEK1/2 inhibitor. U0126's specificity in targeting MEK disrupts the MAPK/ERK pathway, relieving negative feedback loops and facilitating Sos 2 activation.
Calyculin A, another significant activator, operates by inhibiting protein phosphatases, particularly PP1 and PP2A. This inhibition alters phosphorylation events within pathways associated with Sos 2 regulation, ultimately enhancing Sos 2 activation. Additionally, compounds like Forskolin and A23187 act indirectly by modulating cAMP levels and intracellular calcium, respectively. These alterations influence Sos 2 through cAMP-dependent and calcium-dependent signaling cascades, contributing to the fine-tuning of the cellular environment to favor Sos 2 activation. These activators play a pivotal role in navigating the complex landscape of cellular responses, emphasizing the specificity and intricacy of mechanisms governing Sos 2 activity. Their impact extends beyond simple activation, highlighting the dynamic regulatory networks involved in Sos 2 activation across diverse cellular contexts. By understanding the nuanced interplay between these chemicals and the pathways they engage, valuable insights emerge, shedding light on the dynamic regulatory networks that govern Sos 2 activation in various cellular environments.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a selective protein kinase C (PKC) inhibitor. PKC is known to modulate multiple signaling pathways, including the Ras pathway. Inhibition of PKC by this compound can indirectly activate Sos 2 by preventing its negative regulation through PKC-mediated signaling cascades. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases, particularly PP1 and PP2A. By inhibiting these phosphatases, Calyculin A disrupts the balance of phosphorylation events in signaling pathways, including those associated with Sos 2 regulation, leading to enhanced activation of Sos 2 and downstream signaling pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks), affecting the PI3K/Akt pathway. Sos 2 can be indirectly activated through this pathway, and inhibition of PI3K by LY294002 results in enhanced Sos 2 activity by preventing its inhibition through Akt-mediated pathways. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. Sos 2 activity can be influenced by cAMP-mediated pathways, and Forskolin-induced elevation of cAMP levels can result in the activation of Sos 2 through cAMP-dependent signaling cascades. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels. Sos 2 activation has been linked to calcium-dependent signaling pathways. A23187 can modulate these pathways, leading to enhanced activation of Sos 2 through calcium-mediated signaling events. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). While PKC is generally an inhibitor of the Ras pathway, paradoxically, sustained activation by PMA can lead to downstream activation of Sos 2, possibly through complex feedback mechanisms and pathway crosstalk. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
A769662 is an AMP-activated protein kinase (AMPK) activator. AMPK plays a role in energy homeostasis, and its activation can modulate signaling pathways, including those involving Sos 2. A769662-induced AMPK activation can lead to the indirect activation of Sos 2 through AMPK-mediated cellular responses. | ||||||
FK-866 | 658084-64-1 | sc-205325 sc-205325A | 5 mg 10 mg | $140.00 $245.00 | 12 | |
FK866 is a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), affecting the NAD+ biosynthesis pathway. Sos 2 activity can be influenced by NAD+-dependent signaling events, and FK866-mediated depletion of NAD+ levels may modulate Sos 2 activity by altering cellular energy status. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
Go6976 is a selective inhibitor of protein kinase C (PKC) with a preference for conventional PKC isoforms. Similar to Bisindolylmaleimide I, Go6976 can indirectly activate Sos 2 by inhibiting PKC-mediated signaling cascades, relieving negative regulation on Sos 2 and facilitating its activation in relevant cellular contexts. | ||||||
Trametinib | 871700-17-3 | sc-364639 sc-364639A sc-364639B | 5 mg 10 mg 1 g | $112.00 $163.00 $928.00 | 19 | |
Trametinib is a selective MEK1/2 inhibitor. As Sos 2 is a key component of the MAPK/ERK pathway, inhibition of MEK by Trametinib can lead to the activation of Sos 2 by disrupting downstream negative feedback loops within the pathway. | ||||||