Molecular structure of FK-866, CAS Number: 658084-64-1
FK-866 (CAS 658084-64-1)
See product citations (12)
Alternate Names:
K 22.175; N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide
Application:
FK-866 is A highly specific non-competitive inhibitor of NAMPT
CAS Number:
658084-64-1
Purity:
≥98%
Molecular Weight:
391.5
Molecular Formula:
C24H29N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
FK-866 may act to induce apoptosis by non-competitive, and specific inhibition of PBEF (nicotamide phosphoribosyltransferase, NAMPT). PBEF (NAMPT) is a key regulatory enzyme that mediates NAD+ biosynthesis within cells. Mechanistic studies show that this compound contains an enzymatic active site of visfatin which is optimized for nicotinamide binding and inhibition. Visfatin also contains a similar structure to insulin and mimics its actions by binding to the insulin receptors.
FK-866 (CAS 658084-64-1) References
- FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. | Hasmann, M. and Schemainda, I. 2003. Cancer Res. 63: 7436-42. PMID: 14612543
- Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma. | Drevs, J., et al. 2003. Anticancer Res. 23: 4853-8. PMID: 14981935
- Crystal structure of visfatin/pre-B cell colony-enhancing factor 1/nicotinamide phosphoribosyltransferase, free and in complex with the anti-cancer agent FK-866. | Kim, MK., et al. 2006. J Mol Biol. 362: 66-77. PMID: 16901503
- Extension of human cell lifespan by nicotinamide phosphoribosyltransferase. | van der Veer, E., et al. 2007. J Biol Chem. 282: 10841-5. PMID: 17307730
- NAD depletion by FK866 induces autophagy. | Billington, RA., et al. 2008. Autophagy. 4: 385-7. PMID: 18227641
- Nicotinamide mononucleotide adenylyltransferase 1 gene NMNAT1 regulates neuronal dendrite and axon morphogenesis in vitro. | Zhao, H., et al. 2011. Chin Med J (Engl). 124: 3373-7. PMID: 22088538
- Hepatectomy-related hypophosphatemia: a novel phosphaturic factor in the liver-kidney axis. | Nomura, K., et al. 2014. J Am Soc Nephrol. 25: 761-72. PMID: 24262791
- Nicotinamide phosphoribosyltransferase inhibitor is a novel therapeutic candidate in murine models of inflammatory lung injury. | Moreno-Vinasco, L., et al. 2014. Am J Respir Cell Mol Biol. 51: 223-8. PMID: 24588101
- NAMPT regulates mitochondria biogenesis via NAD metabolism and calcium binding proteins during skeletal muscle contraction. | Kim, JS., et al. 2014. J Exerc Nutrition Biochem. 18: 259-66. PMID: 25566462
- Nutritional energy stimulates NAD+ production to promote tankyrase-mediated PARsylation in insulinoma cells. | Zhong, L., et al. 2015. PLoS One. 10: e0122948. PMID: 25876076
- The sensitivity of adipose tissue visfatin mRNA expression to lipopolysaccharide-induced endotoxemia is increased by ovariectomy in female rats. | Iwasa, T., et al. 2016. Int Immunopharmacol. 35: 243-247. PMID: 27083000
- Nicotinamide Phosphoribosyltransferase Attenuates Methotrexate Response in Juvenile Idiopathic Arthritis and In Vitro. | Funk, RS., et al. 2016. Clin Transl Sci. 9: 149-57. PMID: 27166432
- Inhibitor of Nicotinamide Phosphoribosyltransferase Sensitizes Glioblastoma Cells to Temozolomide via Activating ROS/JNK Signaling Pathway. | Feng, J., et al. 2016. Biomed Res Int. 2016: 1450843. PMID: 28097126
- Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody-Drug Conjugates. | Neumann, CS., et al. 2018. Mol Cancer Ther. 17: 2633-2642. PMID: 30242091
- FK866 attenuates sepsis-induced acute lung injury through c-jun-N-terminal kinase (JNK)-dependent autophagy. | Zheng, Q., et al. 2020. Life Sci. 250: 117551. PMID: 32179075
- FK866 inhibits colorectal cancer metastasis by reducing NAD+ levels in cancer-associated fibroblasts. | Xie, H., et al. 2022. Genes Genomics. 44: 1531-1541. PMID: 36214983
Inhibitor of:
ART1, ATP-citrate synthase, BST-1, CLCP1, LOC338588, LOC642366, MIBP, NADK, NAPRT, NBPF1, Nix, NMNAT-1, NMNAT-2, NMNAT-3, PBEF, Proliferin-2, PTPRH, and TGase6.Activator of:
γ Enolase, CARD 11, FHL-2, HGFL, Histone cluster 1 H2BC, Histone cluster 1 H3E, PBEF, PRAMEF17, and Sos 2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FK-866, 5 mg | sc-205325 | 5 mg | $143.00 | |||
FK-866, 10 mg | sc-205325A | 10 mg | $250.00 |