SNX5 Activators
The class of SNX5 activators comprises a diverse array of chemicals that intricately modulate the activity of Sorting Nexin 5 (SNX5), a key player in endosomal sorting and membrane trafficking. These activators exert their influence through both direct and indirect mechanisms, collectively shaping the regulatory networks governing SNX5 function. Direct activators within this class include Wortmannin, LY294002, U0126, Chloroquine, Bafilomycin A1, 3-Methyladenine, SB203580, Pitstop 2, Spautin-1, Leptomycin B, 5'-N-Ethylcarboxamidoadenosine, and PI-103. Wortmannin and LY294002, both PI3K inhibitors, impact the PI3K/Akt pathway, affecting the levels of phosphoinositides critical for SNX5 activation. U0126, a MEK1/2 inhibitor, disrupts the MAPK pathway, indirectly influencing SNX5 through altered phosphorylation of proteins involved in vesicular transport. Chloroquine and Bafilomycin A1, affecting endosomal pH and autophagy, indirectly activate SNX5 by modifying the endosomal environment. 3-Methyladenine, an inhibitor of class III PI3K, modulates autophagy, impacting SNX5-associated endosomal sorting. SB203580, a p38 MAPK inhibitor, indirectly activates SNX5 through the MAPK pathway.
Pitstop 2, a clathrin inhibitor, interferes with clathrin-mediated endocytosis, influencing SNX5-related endosomal sorting. Spautin-1, a USP10/USP13 inhibitor, promotes class III PI3K degradation, impacting autophagy and SNX5 function. Leptomycin B, a nuclear export inhibitor, indirectly activates SNX5 by influencing nuclear export processes. 5'-N-Ethylcarboxamidoadenosine, an adenosine receptor agonist, modulates endosomal acidification and autophagy, indirectly activating SNX5. PI-103, a dual PI3K/mTOR inhibitor, impacts the PI3K/Akt/mTOR pathway, influencing SNX5 through altered phosphoinositide activity. Indirect activators, such as Curcumin, Resveratrol, and 2-Deoxyglucose, modulate cellular pathways like Wnt/β-catenin, SIRT1, and glycolysis, influencing the expression and activity of SNX5. By inhibiting repressive pathways or inducing cellular stress, these compounds create a conducive environment for SNX5 activation.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a fungal metabolite that acts as a phosphoinositide 3-kinase (PI3K) inhibitor, influencing the PI3K/Akt pathway. Its inhibition of PI3K results in altered endosomal trafficking and influences SNX5 activation by modulating phosphoinositide levels, crucial for SNX5's function in endosomal sorting and membrane trafficking. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is a macrolide antibiotic that inhibits vacuolar-type H+ ATPase (V-ATPase), affecting endosomal pH and autophagy. Through these mechanisms, Bafilomycin A1 indirectly activates SNX5, as SNX5 is involved in endosomal sorting. The altered endosomal environment due to V-ATPase inhibition impacts SNX5 activation and its subsequent role in membrane trafficking processes. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
3-Methyladenine is an inhibitor of class III PI3K, impacting autophagy. By modulating the autophagic pathway, 3-Methyladenine indirectly activates SNX5, as SNX5 is associated with endosomal sorting and membrane trafficking. The altered autophagic flux influences SNX5 activation and its subsequent function in cellular processes related to endosomal dynamics and vesicle transport. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor, disrupting the MAPK signaling pathway. This indirect activation of SNX5 occurs through the p38 MAPK pathway's influence on endosomal sorting and membrane trafficking. SB203580 alters cellular processes that impact SNX5 function by modulating the phosphorylation status of proteins involved in vesicular transport, ultimately influencing SNX5 activation. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $165.00 | ||
Spautin-1 is an inhibitor of USP10 and USP13, promoting the degradation of class III PI3K complexes and impacting autophagy. By modulating autophagy, Spautin-1 indirectly activates SNX5, as SNX5 is associated with endosomal sorting and membrane trafficking. The altered autophagic flux influences SNX5 activation and its subsequent function in cellular processes related to endosomal dynamics and vesicle transport. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Leptomycin B is a nuclear export inhibitor that impacts CRM1-dependent nuclear export. By interfering with nuclear export processes, Leptomycin B indirectly activates SNX5, as SNX5 is involved in endosomal sorting. The altered nuclear export pathway influences SNX5 activation and its subsequent role in membrane trafficking processes. | ||||||
PI-103 | 371935-74-9 | sc-203193 sc-203193A | 1 mg 5 mg | $32.00 $128.00 | 3 | |
PI-103 is a dual inhibitor of PI3K and mTOR, impacting the PI3K/Akt/mTOR pathway. By inhibiting PI3K and mTOR, PI-103 indirectly activates SNX5, as SNX5 is regulated by phosphoinositides and associated with endosomal sorting. The altered activity of PI3K and mTOR influences SNX5 activation and its subsequent role in cellular processes related to endosomal dynamics and vesicle transport. | ||||||