Snurportin-1 Activators
Snurportin-1 is a pivotal protein in cellular mechanics, functioning as a courier that facilitates the transport of essential molecular components into the nucleus. Specifically, it binds to the m3G-cap of U snRNPs, which are integral to the spliceosome, a complex that is critical for the splicing of pre-mRNA. The function of Snurportin-1 extends beyond mere transportation; it also signifies the intricate regulation of gene expression and nucleocytoplasmic trafficking. The expression of Snurportin-1 itself is subject to the dynamic regulatory environment of the cell, which can be influenced by a variety of biochemical signals and molecular interactions. As cells react to internal and external cues, the level of Snurportin-1 can be a reflection of the cell's adaptative responses to maintain homeostasis and function.
In the context of cellular regulation, certain chemical compounds, often referred to as activators, can play a significant role in upregulating the expression of proteins like Snurportin-1. These activators can induce expression by engaging with cellular pathways and modifying the interaction between regulatory proteins and DNA. For instance, compounds that inhibit enzymes like histone deacetylases can lead to a more relaxed chromatin structure, thereby increasing the accessibility of transcription factors to DNA. Additionally, substances that inhibit DNA methyltransferases can reduce methylation levels, often resulting in the transcriptional activation of genes. Other activators may work by modulating signal transduction pathways, such as those involving cAMP or protein kinase C, which can result in the phosphorylation of transcription factors and a subsequent rise in gene expression levels. It is through these multifaceted mechanisms that such activators can potentially induce the expression of Snurportin-1, highlighting the intricate interplay between chemical signaling and genetic regulation within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is known to upregulate gene expression by inhibiting histone deacetylase, resulting in a less compact and more transcriptionally active chromatin structure, which could enhance the transcription of Snurportin-1. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine can lead to the hypomethylation of gene promoter regions, potentially increasing the transcription rate of genes including Snurportin-1. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels, leading to the activation of the transcription factor CREB, which may stimulate the transcription of genes responsive to cAMP including Snurportin-1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid serves as an agonist for retinoic acid receptors, which can bind to retinoic acid response elements in gene promoters and upregulate genes such as Snurportin-1. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone binds to glucocorticoid receptors and may stimulate the transcription of genes by initiating the binding of the receptor complex to glucocorticoid response elements, potentially enhancing Snurportin-1 expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can lead to the phosphorylation of transcription factors and subsequent upregulation of their target genes, possibly including Snurportin-1. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, as an HDAC inhibitor, can lead to increased acetylation of histones, thereby promoting a transcriptionally permissive environment that may enhance Snurportin-1 expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate has been shown to stimulate gene expression through the inhibition of DNA methyltransferases and histone deacetylases, which could promote the transcription of Snurportin-1. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuin proteins, which can lead to the deacetylation of transcription factors and the subsequent upregulation of their target genes, including potentially Snurportin-1. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3 (GSK-3), which may result in the stabilization and activation of transcription factors that stimulate gene expression, potentially including Snurportin-1. | ||||||