SNAPC 19 Inhibitors
Chemical inhibitors of SNAPC 19 operate through various biochemical pathways to modulate the function of this protein, which plays a pivotal role in the transcription initiation process. Bisindolylmaleimide I, Gö6976, Ro-31-8220, and Calphostin C are all inhibitors of protein kinase C (PKC). By inhibiting PKC, these compounds can directly alter the phosphorylation state of SNAPC 19, which is crucial for its ability to interact with other components of the transcription machinery. Calphostin C is unique among these as it requires photoactivation to exert its inhibitory effects. The consistent theme among these chemicals is their capacity to disrupt the phosphorylation-dependent regulatory mechanisms that enable SNAPC 19 to contribute to the assembly and function of the transcription initiation complex.
Further modulating the activity of SNAPC 19, ML-7 takes a different approach by targeting myosin light chain kinase (MLCK). Inhibition of MLCK by ML-7 can influence cytoskeletal dynamics and cellular transport, which may affect the localization and stability of SNAPC 19, consequently modulating its function in transcription. Similarly, inhibitors of phosphoinositide 3-kinases, such as Wortmannin and LY294002, disrupt upstream signaling pathways that can indirectly modulate the function of SNAPC 19. The MEK1/2 inhibitor U0126 and p38 MAP kinase inhibitor SB203580 affect the MAPK signaling pathway, which is known to regulate a variety of transcriptional processes. By inhibiting these kinases, these chemicals can affect the phosphorylation and activity of transcriptional regulators, potentially impacting SNAPC 19's role. Lastly, H-89 and KT5720, as inhibitors of protein kinase A (PKA), and SP600125, an inhibitor of c-Jun N-terminal kinase (JNK), can each influence the phosphorylation landscape within the cell, thereby modulating the functional activity of transcription components such as SNAPC 19. Each of these chemicals, through their respective targets, can disrupt the normal phosphorylation and functioning of SNAPC 19 in the transcription initiation complex.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of protein kinase C (PKC). Inhibition of PKC can affect the phosphorylation state of SNAPC 19, potentially impairing its ability to properly engage with the transcription machinery or other protein partners crucial for its function. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $227.00 | 8 | |
Gö6976 is a potent inhibitor of PKC, particularly isoforms α and β. By inhibiting PKC, Gö6976 can alter the phosphorylation of SNAPC 19, leading to a decrease in its activity as part of the SNAP complex involved in transcription initiation. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK). By inhibiting MLCK, ML-7 can reduce the phosphorylation of myosin light chains, potentially impacting the cytoskeletal dynamics and cellular transport mechanisms that could be required for the proper localization and function of SNAPC 19. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K). PI3K pathways can regulate transcription factors and machinery, possibly disrupting processes that are essential for the activity of SNAPC 19 in transcription initiation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another well-known inhibitor of PI3K. By inhibiting PI3K, LY294002 can interfere with the signaling pathways that regulate transcription machinery, which can lead to functional inhibition of SNAPC 19 by impeding its role in the transcription initiation complex. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $92.00 $245.00 | 17 | |
Ro-31-8220 is a broad-spectrum PKC inhibitor. Through its inhibition of PKC, it can prevent the phosphorylation of SNAPC 19, thus potentially inhibiting its function in the formation of the transcription initiation complex. | ||||||
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $343.00 $1642.00 | 20 | |
Calphostin C is a specific inhibitor of PKC that requires light activation. It can prevent the phosphorylation of SNAPC 19, leading to the inhibition of its transcription regulatory functions. | ||||||
KT 5720 | 108068-98-0 | sc-3538 sc-3538A sc-3538B | 50 µg 100 µg 500 µg | $138.00 $220.00 $972.00 | 47 | |
KT5720 is another PKA inhibitor. By inhibiting PKA, KT5720 may interfere with the phosphorylation and therefore the functional activity of SNAPC 19 within the transcription initiation complex. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2 which are upstream of ERK in the MAPK pathway. Inhibition of this pathway can lead to reduced activation of transcriptional regulators and may inhibit the function of SNAPC 19 in initiating transcription. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is an inhibitor of p38 MAP kinase. p38 MAP kinase can influence transcription and its inhibition by SB203580 could lead to a decrease in the functional activity of SNAPC 19 in transcription regulation. | ||||||