SNAPC 19 Antibody (9K8): sc-135565

SNAPC 19 Antibody (9K8) is a mouse monoclonal IgG2a kappa light chain antibody that detects SNAPC 19 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SNAPC 19 antibody (9K8) is available as the non-conjugated format. SNAPC 19 plays a crucial role in gene transcription regulation, particularly in assembling the snRNA-activating protein complex (SNAPC), which is essential for RNA polymerase II and III transcription. SNAPC 19 binds to a non-TATA-box proximal sequence element, facilitating recruitment of transcription factors such as Oct-1 and TATA-box binding protein (TBP). SNAPC 19′s interaction with Oct-1 enhances transcriptional activation of small nuclear RNAs (snRNAs) by stabilizing binding of these factors to respective DNA elements. SNAPC 19 contributes to SNAPC complex assembly, which consists of five subunits of varying sizes, each contributing to overall transcription regulator functionality. Understanding SNAPC 19′s role in transcription regulation provides insights into gene expression mechanisms and potential implications in various biological processes and diseases.

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SNAPC 19 Antibody (9K8) References:

1. A positioned nucleosome on the human U6 promoter allows recruitment of SNAPc by the Oct-1 POU domain.  |  Zhao, X., et al. 2001. Mol Cell. 7: 539-49. PMID: 11463379
2. A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III.  |  Henry, RW., et al. 1995. Nature. 374: 653-6. PMID: 7715707
3. Targeting TBP to a non-TATA box cis-regulatory element: a TBP-containing complex activates transcription from snRNA promoters through the PSE.  |  Sadowski, CL., et al. 1993. Genes Dev. 7: 1535-48. PMID: 8339931
4. The SNAP45 subunit of the small nuclear RNA (snRNA) activating protein complex is required for RNA polymerase II and III snRNA gene transcription and interacts with the TATA box binding protein.  |  Sadowski, CL., et al. 1996. Proc Natl Acad Sci U S A. 93: 4289-93. PMID: 8633057
5. Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc.  |  Henry, RW., et al. 1996. EMBO J. 15: 7129-36. PMID: 9003788
6. Role for the amino-terminal region of human TBP in U6 snRNA transcription.  |  Mittal, V. and Hernandez, N. 1997. Science. 275: 1136-40. PMID: 9027316
7. Characterization of a trimeric complex containing Oct-1, SNAPc, and DNA.  |  Ford, E. and Hernandez, N. 1997. J Biol Chem. 272: 16048-55. PMID: 9188510
8. SNAP19 mediates the assembly of a functional core promoter complex (SNAPc) shared by RNA polymerases II and III.  |  Henry, RW., et al. 1998. Genes Dev. 12: 2664-72. PMID: 9732265
9. The Oct-1 POU domain activates snRNA gene transcription by contacting a region in the SNAPc largest subunit that bears sequence similarities to the Oct-1 coactivator OBF-1.  |  Ford, E., et al. 1998. Genes Dev. 12: 3528-40. PMID: 9832505

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SNAPC 19 Antibody (9K8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SNAPC 19 Antibody (9K8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SNAPC 19 Antibody (9K8) Specifications

Alternate Product Name: SNAPC 19

Product Clone Name: 9K8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-69

Epitope Target: SNAPC 19

Epitope Species: human

Product Reactivity/Detection: SNAPC 19

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SNAPC 19 Antibody (9K8): N/A