SMMHC Inhibitors
SMMHC inhibitors are a class of chemical compounds that specifically target and inhibit the function of smooth muscle myosin heavy chain (SMMHC), a key component of the contractile machinery in smooth muscle cells. SMMHC plays a crucial role in facilitating muscle contraction by interacting with actin filaments in a process powered by ATP hydrolysis. This interaction is vital for various physiological processes, such as regulating the tone and movement of smooth muscle tissues found in organs like blood vessels, the gastrointestinal tract, and the respiratory system. Inhibiting SMMHC disrupts the normal function of this contractile system, affecting the ability of smooth muscle cells to contract and respond to stimuli.
Researchers use SMMHC inhibitors to study the molecular mechanisms that govern smooth muscle contraction and to explore how changes in SMMHC activity affect cellular behavior and mechanical processes. By blocking SMMHC function, scientists can observe alterations in the dynamic regulation of actin-myosin interactions, providing insights into how smooth muscle cells maintain structural integrity and manage force generation. Additionally, SMMHC inhibitors help elucidate the broader roles of myosin-heavy chains in cytoskeletal organization and intracellular transport. Investigating the effects of these inhibitors on smooth muscle cells can reveal critical details about the regulation of contractility and how the inhibition of SMMHC impacts related cellular processes, further advancing our understanding of muscle mechanics and cytoskeletal function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a potent histone deacetylase inhibitor that can lead to hyperacetylation of histones, thereby loosening chromatin structure and downregulating SMMHC expression through transcriptional repression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine's incorporation into DNA can lead to the hypomethylation of gene promoter regions, which could specifically result in the decreased transcription of the MYH11 gene, consequently reducing SMMHC levels. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A specifically binds to DNA and can interfere with the binding of transcriptional activators to the MYH11 promoter, leading to a decrease in SMMHC expression by preventing initiation of its transcription. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is an inhibitor of MEK, which can lead to the suppression of the ERK pathway, resulting in the downregulation of transcription factors that are crucial for SMMHC expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 selectively inhibits p38 MAPK, which can lead to a decrease in the phosphorylation of transcription factors that drive SMMHC expression, thereby reducing its expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 inhibits PI3K, leading to a reduction in AKT phosphorylation and subsequent downstream signaling necessary for the transcriptional initiation of genes including MYH11, thereby decreasing SMMHC expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a kinase involved in cell growth and proliferation, which could result in a decrease in the overall protein synthesis machinery, including the synthesis of SMMHC. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 inhibits ROCK kinase activity, which can result in a reduction of phosphorylation of downstream targets that are necessary for maintaining SMMHC expression in smooth muscle cells. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective inhibitor of JNK, which is involved in the control of gene expression. Its inhibition can result in the downregulation of transcription factors required for SMMHC expression. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits MEK1/2, resulting in the inhibition of ERK1/2 phosphorylation, which is essential for the transcription of various genes, potentially leading to a decrease in SMMHC expression. | ||||||