SmcY Inhibitors
Chemical inhibitors termed "SmcY inhibitors," in a broad sense, would encompass a variety of chemical classes, each designed to interact with specific domains or active sites within a protein or to interrupt protein-protein interactions relevant to the activity of "SmcY". These inhibitors would generally be characterized by their ability to bind to the target protein with high specificity and affinity, thereby modulating its function.
The inhibitors listed encompass a range of biochemical mechanisms such as kinase inhibition, proteasome inhibition, and signaling pathway interference. They often mimic the structure of natural substrates or competitive molecules and can either block the active site or alter the conformation of the protein to prevent its normal function. This action on signaling pathways illustrates a method by which cellular processes are modulated at a molecular level, affecting the function of "SmcY" indirectly through upstream or downstream effects within a given pathway. The molecules cited include both reversible and irreversible inhibitors, small molecules, and more complex structures, all of which can profoundly impact the biological activity of target proteins within the implicated pathways.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent kinase inhibitor affecting a wide range of kinases, which could inhibit "SmcY" activity if it phosphorylates or is activated by phosphorylation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that would inhibit the PI3K-Akt signaling pathway. If "SmcY" is downstream of PI3K or Akt, this inhibition can decrease its activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a key protein in cell growth and metabolism signaling pathways. If "SmcY" is regulated by mTOR, rapamycin can suppress its activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. Inhibition of p38 MAPK can affect "SmcY" if it is a part of or is regulated by the p38 MAPK signaling pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor. If "SmcY" is involved in the JNK signaling pathway, its activity would be affected by this compound. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which would affect "SmcY" if it is part of the MAPK/ERK pathway or if its activity is modulated by this pathway. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib inhibits the proteasome, potentially decreasing the degradation of inhibitory proteins that control "SmcY" activity or increasing the degradation of "SmcY" itself if it is a substrate. | ||||||
ZM 336372 | 208260-29-1 | sc-202857 | 1 mg | $46.00 | 2 | |
ZM336372 is a specific inhibitor of Raf-1 kinase. If "SmcY" activity is dependent on the Raf/MEK/ERK signaling pathway, this compound can decrease its activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K. Inhibition of PI3K would lead to decreased activity of "SmcY" if it is regulated by or involved in the PI3K signaling pathway. | ||||||
Imatinib mesylate | 220127-57-1 | sc-202180 sc-202180A | 25 mg 100 mg | $44.00 $109.00 | 61 | |
Imatinib is a tyrosine kinase inhibitor, primarily targeting BCR-ABL, c-Kit, and PDGF receptors. If "SmcY" is a tyrosine kinase or is regulated by tyrosine kinase signaling, imatinib could inhibit its function. | ||||||