SMC4 Activators
SMC4 Activators is a term that refers to a class of chemicals that can influence the activity of the Structural Maintenance of Chromosomes 4 (SMC4) protein, either directly or indirectly. The SMC4 protein is a key component of the condensin complex, which plays a pivotal role in chromosome condensation and segregation during mitosis and meiosis. Activators of SMC4, therefore, can potentially modulate these critical cellular processes. The mechanisms by which these chemicals modulate SMC4 activity can be diverse. For instance, some activators might alter the phosphorylation state of the condensin complex, affecting its function and thus the activity of SMC4.
Other chemicals might influence SMC4 activity by altering chromatin structure, as the condensin complex, including SMC4, interacts with chromatin to perform its functions. Still, others might modulate the stability and activity of the condensin complex by influencing molecular chaperones that interact with the complex. Hence, the term SMC4 Activators can include a broad range of chemicals with varying mechanisms of action, all converging on the potential to modulate the activity of the SMC4 protein. It is a field of ongoing research, with many nuances and complexities yet to be fully understood. As our knowledge of cellular processes and molecular interactions continues to grow, the understanding of what constitutes an SMC4 Activator will likely continue to evolve.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
RO-3306 | 872573-93-8 | sc-358700 sc-358700A sc-358700B | 1 mg 5 mg 25 mg | $66.00 $163.00 $326.00 | 37 | |
RO-3306 is a specific inhibitor of Cdk1. Since Cdk1 can phosphorylate the condensin complex (where SMC4 is a component), inhibiting Cdk1 may indirectly influence SMC4 activity. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $72.00 $297.00 | 4 | |
Purvalanol A is an inhibitor of Cdk1. By inhibiting Cdk1, it may indirectly affect the phosphorylation of the condensin complex and subsequently the activity of SMC4. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is an inhibitor of histone deacetylase (HDAC). By inhibiting HDAC, it can alter chromatin structure, which may indirectly influence the activity of SMC4 as part of the condensin complex. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat is another HDAC inhibitor. By modifying chromatin structure through HDAC inhibition, it may indirectly influence the activity of the condensin complex and SMC4. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin is a DNA damaging agent. By inducing DNA damage, it may indirectly stimulate the DNA repair activity of the condensin complex, including SMC4. | ||||||
ICRF-193 | 21416-68-2 | sc-200889 sc-200889A | 1 mg 5 mg | $341.00 $927.00 | 7 | |
ICRF-193 is a Topoisomerase II inhibitor. By inhibiting Topoisomerase II, it may indirectly influence the interaction between the condensin complex and Topoisomerase II, potentially impacting SMC4 activity. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin is an inhibitor of Hsp90, a molecular chaperone that interacts with the condensin complex. By inhibiting Hsp90, it may indirectly impact the stability and activity of the condensin complex and SMC4. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG is another Hsp90 inhibitor. By inhibiting Hsp90, it may indirectly influence the stability and activity of the condensin complex, including SMC4. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is an inhibitor of protein phosphatases PP1 and PP2A. By inhibiting these phosphatases, it may indirectly influence a wide array of signaling pathways, potentially influencing the condensin complex and SMC4 activity. | ||||||