SMC2 Activators
SMC2 Activators are a class of chemical compounds that enhance the functional activity of SMC2 through distinct pathways. Resveratrol and Forskolin enhance SMC2 indirectly through SIRT1 and adenylate cyclase pathways, respectively. Resveratrol's SIRT1 pathway activation results in deacetylation of proteins, promoting cellular homeostasis for SMC2 operation, while Forskolin's adenylate cyclase pathway activation elevates intracellular cAMP levels, optimizing SMC2 transport conditions. The NF-κB pathway is inhibited by both EGCG and Silymarin, reducing the production of proteins that negatively regulate SMC2. Similarly, the JAK-STAT and PI3K/AKT pathways are inhibited by Curcumin, Quercetin, and Genistein, also reducing the production of SMC2-negative proteins.
The TRPV1 pathway, activated by Capsaicin and Piperine, changes the ionic balance within the cell, optimizing SMC2 transport conditions. SMC2 is also indirectly enhanced by Metformin and Berberine, which activate the AMPK pathway, optimizing metabolism and energy homeostasis for SMC2 operation. Finally, Sulforaphane activates the Nrf2 antioxidant pathway, reducing oxidative stress, which can be detrimental to SMC2 function. These chemicals, through their direct or indirect influence on related pathwaysand cellular processes, promote the functional enhancement of SMC2.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol enhances SMC2 indirectly by activating the SIRT1 pathway. SIRT1, a NAD+-dependent deacetylase, deacetylates numerous proteins, promoting cellular homeostasis for optimal SMC2 operation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin enhances SMC2 indirectly by activating the adenylate cyclase pathway. This activation increases intracellular levels of cAMP, optimizing the transport conditions for SMC2. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG enhances SMC2 indirectly by inhibiting the NF-κB pathway. This inhibition reduces the production of proteins that negatively regulate SMC2, enhancing its functional activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin enhances SMC2 indirectly by inhibiting the JAK-STAT pathway. By inhibiting this pathway, Curcumin reduces the production of proteins that negatively regulate SMC2, enhancing its functional activity. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin enhances SMC2 indirectly by activating the TRPV1 pathway, which leads to changes in ionic balance in the cell. These changes optimize the transport conditions for SMC2, enhancing its functional activity. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
Metformin enhances SMC2 indirectly by activating the AMPK pathway. AMPK optimizes metabolism and energy homeostasis. The activation of AMPK optimizes the cellular energy status for SMC2 operation, enhancing its functional activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin enhances SMC2 indirectly by inhibiting the PI3K/AKT pathway. By inhibiting this pathway, Quercetin reduces the production of proteins that negatively regulate SMC2, enhancing its functional activity. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine enhances SMC2 indirectly by activating the AMPK pathway, similar to Metformin. By activating AMPK, Berberine optimizes the cellular energy status for SMC2 operation, enhancing its functional activity. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $319.00 | ||
Silymarin enhances SMC2 indirectly by inhibiting the NF-κB pathway, similar to EGCG. By inhibiting NF-κB, Silymarin reduces the production of proteins that negatively regulate SMC2, enhancing its functional activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein enhances SMC2 indirectly by inhibiting the PI3K/AKT pathway, similar to Quercetin. By inhibiting this pathway, Genistein reduces the production of proteins that negatively regulate SMC2, enhancing its functional activity. | ||||||