Slfn12 Activators
Slfn12 Activators are a diverse group of chemical compounds that indirectly enhance the functional activity of Slfn12 through various signaling pathways and cellular processes. Compounds like Forskolin and IBMX increase intracellular levels of cAMP, potentially activating PKA, which may then influence substrates and pathways interacting with Slfn12, particularly those involved in RNA processing or immune responses. Similarly, PMA, as a PKC activator, and (-)-Epigallocatechin Gallate, known for its broad signaling modulation, may alter the cellular signaling milieu in ways that indirectly affect Slfn12 activity, especially in immune function and stress response. LY 294002 and U0126, as inhibitors of PI3K and MEK respectively, could lead to changes in cell survival and stress signaling pathways, potentially creating a context where Slfn12's role is enhanced. Additionally, Sildenafil and A23187 influence cellular levels of cGMP and calcium, respectively, each contributing to a signaling environment that might augment Slfn12's activity in various cellular processes.
Moreover, Staurosporine, despite its general inhibitory action on kinases, might shift signaling equilibria in a manner that indirectly supports Slfn12 activity, especially in contexts of cellular stress or apoptosis. Sodium Butyrate, by influencing gene expression, and Curcumin and Resveratrol, through their modulation of inflammation and oxidative stress pathways, may also create cellular conditions that favor Slfn12's functional activity. These chemicals, through their targeted effects on signaling molecules and pathways, facilitate the enhancement of Slfn12-mediated functions, particularly those related to immune response, stress adaptation, and possibly RNA processing, without the need for direct upregulation of its expression or activation, highlighting the complex and interconnected nature of cellular signaling in regulating protein activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates intracellular cAMP levels, which in turn can activate PKA. Activated PKA may phosphorylate specific substrates that could indirectly enhance the functional activity of Slfn12 by promoting its association with other proteins or substrates within the cell, thereby facilitating its role in RNA processing or immune response. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, leading to increased cAMP and cGMP levels in cells. The elevation of these cyclic nucleotides could indirectly enhance Slfn12 activity by similar mechanisms as Forskolin, involving PKA activation and subsequent cellular processes that may involve Slfn12. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Protein Kinase C (PKC), which is involved in controlling numerous cellular functions. PKC activation might influence Slfn12 activity by modifying cellular signaling cascades that Slfn12 is part of, especially those related to immune function or cell growth regulation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
(-)-Epigallocatechin Gallate is a type of catechin found in green tea with antioxidant properties. It may modulate various signaling pathways, potentially influencing Slfn12 activity by altering cellular environments and signaling pathways in which Slfn12 is involved, such as stress response or immune signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002 is a PI3K inhibitor, reducing AKT phosphorylation and influencing various downstream signaling pathways. By inhibiting PI3K, it might indirectly affect Slfn12 activity by altering the cellular signaling environment, especially those related to cell survival and metabolism that Slfn12 may interact with. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels. Elevated calcium can activate various calcium-dependent kinases and phosphatases, potentially affecting Slfn12 activity by influencing signaling pathways or cellular processes where Slfn12 is implicated. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent kinase inhibitor with broad specificity. While it generally inhibits kinases, it might lead to a shift in cellular signaling balance, potentially affecting pathways that indirectly enhance Slfn12 activity, especially in stress or apoptosis-related pathways. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate is a short-chain fatty acid and HDAC inhibitor, affecting gene expression and cellular signaling. While not directly activating Slfn12, it may create a cellular environment conducive to Slfn12 activity by affecting gene expression patterns and cellular stress responses. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin influences multiple signaling pathways, including inflammation and oxidative stress pathways. By modulating these pathways, it may create conditions that indirectly enhance Slfn12's functional activity, particularly in immune response or cellular stress environments. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol affects various signaling molecules and pathways, including sirtuins and NF-kB. Its influence on these pathways might indirectly enhance Slfn12 activity by affecting cellular stress responses and metabolic regulation. | ||||||