SLC25A40 Inhibitors
SLC25A40 is a member of the SLC25 family, which encompasses a group of proteins known as mitochondrial carriers. These proteins are embedded in the mitochondrial membrane and are responsible for the transport of a multitude of substrates across the membrane, thereby facilitating the exchange of metabolites, nucleotides, and cofactors that are critical for mitochondrial function and cellular metabolism. SLC25A40, like other members of this family, possesses a characteristic structure that includes six transmembrane helices, forming a channel or pore through which specific molecules can be translocated. SLC25A40 inhibitors, therefore, are chemical entities that can specifically bind to this protein and modulate its activity. By inhibiting SLC25A40, these compounds effectively alter the transport activity, leading to a modulation of the mitochondrial function due to the alteration in the concentration gradients of the transported substrates.
The development and interest in SLC25A40 inhibitors arise from the fundamental role that mitochondrial transporters play in cellular physiology. Inhibitors targeting SLC25A40 are designed to interact with the protein in a way that impedes its normal function, typically by occupying the substrate binding site or by inducing a conformational change that prevents substrate passage. Such inhibition can be competitive, non-competitive, or uncompetitive depending on the inhibitor's mechanism of action and its interaction with the transporter. The specificity and selectivity of SLC25A40 inhibitors are paramount, as off-target effects on other mitochondrial carriers could result in widespread disruption of mitochondrial function. The chemical design of these inhibitors often involves intricate knowledge of the transporter's structure and the chemical properties of the substrate, ensuring that the inhibitor has the appropriate shape, charge distribution, and hydrophobic or hydrophilic characteristics to interact with the SLC25A40 protein effectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin is an inhibitor of mitochondrial ATP synthase. SLC25A40 is implicated in mitochondrial function and energy metabolism. Inhibition of ATP synthase by oligomycin could lead to altered mitochondrial membrane potential and indirectly inhibit the transport function of SLC25A40. | ||||||
Carboxine | 5234-68-4 | sc-234286 | 250 mg | $21.00 | 1 | |
Carboxin inhibits succinate dehydrogenase, part of the mitochondrial respiratory chain. This inhibition can lead to reduced electron transport chain activity, which may affect the mitochondrial function and indirectly inhibit SLC25A40 activity associated with metabolite transport. | ||||||
Bongkrekic acid | 11076-19-0 | sc-205606 | 100 µg | $418.00 | 10 | |
Bongkrekic acid inhibits the adenine nucleotide translocase (ANT) in the mitochondria. By affecting the ANT, the overall mitochondrial membrane potential and ATP/ADP exchange can be altered, potentially leading to decreased SLC25A40 activity due to changes in the mitochondrial inner membrane environment. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A specifically inhibits complex III of the mitochondrial electron transport chain. This inhibition can result in decreased mitochondrial membrane potential, which could indirectly impact SLC25A40's function in mitochondrial transport. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I. By inhibiting this complex, the overall mitochondrial function is compromised, which may lead to a decrease in SLC25A40 activity due to altered mitochondrial membrane potential and matrix composition. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Sodium azide inhibits cytochrome c oxidase in the electron transport chain. This blockade can lead to reduced mitochondrial function which may indirectly affect SLC25A40's role in metabolite transport across the mitochondrial membrane. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $36.00 | 1 | |
TTFA is an inhibitor of mitochondrial complex II. By disrupting the electron transport chain, the mitochondrial membrane potential and overall function can be compromised, potentially leading to decreased activity of SLC25A40, which is involved in the transport of mitochondrial metabolites. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
FCCP uncouples oxidative phosphorylation by dissipating the proton gradient across the mitochondrial membrane. This disrupts ATP synthesis and can indirectly inhibit SLC25A40 by altering the mitochondrial membrane potential and metabolite transport. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-glucose is a glucose analog that inhibits glycolysis. By reducing ATP production, it may indirectly inhibit the energy-dependent functions of SLC25A40 in mitochondrial transport. | ||||||