SKT Inhibitors
SKT inhibitors are chosen for their ability to indirectly influence its function in intervertebral disk development. These inhibitors target various signaling pathways and biological processes that are pivotal in development and cellular differentiation, which could impact SKT's role in the development of intervertebral disks. Compounds like Retinoic Acid, all trans and Cholecalciferol are crucial for embryonic development and bone health, respectively. Their influence on cellular differentiation and development could extend to affect SKT-related processes in intervertebral disk development.
Inhibitors of key signaling pathways like TGF-β (SB 431542), BMP (LDN-193189), Wnt (XAV939), FGF (PD173074), Hedgehog (Cyclopamine), Notch (DAPT), PDGF (Imatinib), mTOR (Rapamycin), and PI3K (LY 294002) provide a broad spectrum of modulators of SKT's function. These pathways are integral to various aspects of cellular development and differentiation, and modulating these pathways could influence the development of intervertebral disks and SKT's role in this process. Dexamethasone, a corticosteroid, is included for its effects on inflammation and cellular differentiation, which can be relevant in the context of intervertebral disk development.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Involved in embryonic development and could indirectly affect SKT's role in intervertebral disk development. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Essential for bone health and development, may have an indirect influence on intervertebral disk development and potentially SKT's function. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
Inhibits TGF-β signaling, which is involved in various developmental processes, potentially affecting pathways related to SKT. | ||||||
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
Inhibits Bone Morphogenetic Protein (BMP) signaling, which plays a role in skeletal development, potentially influencing SKT-related pathways. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
A corticosteroid that influences inflammation and cellular differentiation, could indirectly affect SKT's role in intervertebral disk development. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
Inhibits the Wnt signaling pathway, which is important in development and could influence processes related to SKT's function. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $47.00 $143.00 $680.00 | 16 | |
Inhibits Fibroblast Growth Factor (FGF) signaling, which can be involved in developmental processes, potentially affecting SKT-related pathways. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Inhibits Hedgehog signaling, a pathway important in development, which might indirectly affect SKT's function in intervertebral disk development. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
Inhibits Notch signaling, involved in cell differentiation and development, potentially affecting pathways related to SKT. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $26.00 $119.00 $213.00 | 27 | |
Inhibits Platelet-Derived Growth Factor (PDGF) signaling, which could have implications in developmental processes relevant to SKT's function. | ||||||