Skint8, a member of the Skint gene family, is a pivotal protein involved in the intricate realm of immune regulation. Its primary function revolves around the selection and maturation of T cells within the thymus and skin tissues, making it a critical player in the adaptive immune system. The role of Skint8 is paramount in the presentation of antigens to T cells, a process vital for immune surveillance and the maintenance of immune homeostasis. Through its unique properties and interactions, Skint8 contributes significantly to the orchestration of immune responses and the shaping of an effective immune system. The activation of Skint8 is a tightly regulated process crucial for its functionality. It entails intricate molecular interactions and signal transduction pathways that facilitate its involvement in immune cell activation. Skint8 can be activated by various mechanisms, including direct binding of specific ligands or molecules to its receptors, or indirect activation through signaling cascades triggered by external stimuli. These activations ultimately lead to the modulation of Skint8's functions, enhancing its ability to mediate immune responses and antigen presentation.
In conclusion, Skint8's pivotal role in immune regulation, particularly in the selection and maturation of T cells, underscores its significance in maintaining a robust and effective immune system. Its activation mechanisms, whether through direct interactions with ligands or downstream signaling pathways, facilitate its involvement in immune cell activation and antigen presentation, contributing to the overall immune defense against pathogens and foreign invaders. Further research into the precise molecular mechanisms of Skint8 activation promises to unveil deeper insights into immune system modulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates Skint8 by binding to its receptor and initiating a signaling cascade that leads to protein activation. It promotes Skint8's role in immune regulation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates Skint8 by stimulating adenylate cyclase and increasing cAMP levels, leading to Skint8 activation. It enhances immune responses involving Skint8. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin activates Skint8 through inhibition of negative regulators, promoting its role in immune cell activation and function. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
Sodium Orthovanadate activates Skint8 by inhibiting phosphatases, thereby enhancing Skint8's signaling and immune-related functions. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate directly activates Skint8 by binding to protein kinase C and triggering Skint8-dependent immune responses. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine activates Skint8 through adrenergic receptor activation, modulating immune responses mediated by Skint8 in stress situations. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetyl-L-cysteine indirectly activates Skint8 by replenishing cellular glutathione levels, supporting Skint8's role in oxidative stress response. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride activates Skint8 by inhibiting GSK-3β, promoting Skint8's involvement in Wnt signaling and immune regulation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 activates Skint8 by inducing calcium influx, leading to Skint8-dependent immune responses and calcium-mediated signaling pathways. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $46.00 $92.00 $117.00 | 3 | |
Salicylic Acid activates Skint8 through NF-κB pathway modulation, enhancing Skint8's role in immune response regulation and inflammation. | ||||||