Sir2 Activators
Common Sir2 Activators include, but are not limited to Resveratrol CAS 501-36-0, SRT1720 CAS 1001645-58-4, SRT 1460 CAS 925432-73-1, Quercetin CAS 117-39-5 and Fisetin CAS 528-48-3.
Sir2 Activators refer to a class of chemical compounds that are designed to interact with and modulate the activity of the Sirtuin 2 (Sir2) protein, also known as SIRT2. Sir2 is a member of the sirtuin family of NAD+-dependent deacetylases, a group of enzymes highly conserved across various species, including humans. These enzymes are involved in a wide range of cellular processes, including gene regulation, DNA repair, metabolism, and stress responses. SIRT2, in particular, has been extensively studied for its role in maintaining cellular homeostasis, especially in the context of aging and age-related diseases.
Sir2 activators work by enhancing the enzymatic activity of SIRT2. This activation can occur through various molecular mechanisms, such as direct binding to SIRT2, increasing the availability of its cofactor NAD+, or promoting conformational changes that enhance its catalytic efficiency. Once activated, SIRT2 plays a pivotal role in regulating cellular functions through the deacetylation of target proteins, including histones and transcription factors. By modifying the acetylation status of these proteins, SIRT2 can influence gene expression, chromatin structure, and various signaling pathways, ultimately impacting cellular processes and physiology. The study of Sir2 activators is essential for unraveling the intricate molecular mechanisms underlying the role of SIRT2 in cellular health and longevity.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A natural phenol that activates Sir2 by enhancing its NAD+-dependent deacetylase activity. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $197.00 $364.00 | 13 | |
A synthetic activator that specifically enhances Sir2 deacetylase activity. | ||||||
SRT 1460 | 925432-73-1 | sc-474552 sc-474552A | 1 mg 250 mg | $300.00 $1150.00 | ||
Another synthetic compound known to activate Sir2 by increasing its enzymatic activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid that indirectly activates Sir2 by modulating cellular NAD+ levels. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $52.00 $79.00 $104.00 $156.00 $2913.00 | 7 | |
Acts as an indirect activator of Sir2 through pathways involving NAD+ biosynthesis. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $51.00 $71.00 $199.00 | 11 | |
A natural stilbenoid similar to resveratrol, known to enhance Sir2 activity. | ||||||
Isoliquiritigenin | 961-29-5 | sc-255222 | 10 mg | $316.00 | 1 | |
A flavonoid that can indirectly activate Sir2 by altering NAD+/NADH ratio. | ||||||
Oleuropein | 32619-42-4 | sc-286622 sc-286622A sc-286622B sc-286622C | 500 mg 1 g 10 g 100 g | $359.00 $530.00 $791.00 $6773.00 | 2 | |
A compound in olive oil that can enhance Sir2 activity, though indirectly. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $325.00 | ||
A mixture of flavonolignans from milk thistle, reported to have indirect effects on Sir2. | ||||||
Gallic acid | 149-91-7 | sc-205704 sc-205704A sc-205704B | 10 g 100 g 500 g | $56.00 $87.00 $245.00 | 14 | |
A phenolic acid that potentially influences Sir2 activity indirectly. | ||||||