SRT 1460 (CAS 925432-73-1)
Alternate Names:
SRT 1460 is known as an SIRT1 sirtuin activator.
Application:
SRT 1460 is a drug in development intendede as a small-molecule activator of sirtuin subtype SIRT1.
CAS Number:
925432-73-1
Molecular Weight:
507.60
Molecular Formula:
C26H29N5O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SRT 1460 is a drug in development intendede as a small-molecule activator of sirtuin subtype SIRT1. SRT 1460 shows positive selectivity of SIRT1 versus SIRT2 and SIRT3. In animal studies, SRT 1460 was shown to have similar activity to resveratrol, a known SIRT1 activator. SRT 1460, however, is closer in potency to SRT 1720 than it is to resveratrol. SRT 1460 was observed in animal studies improving insulin sensitivity, lowering plasma glucose levels, and increasing metabolic function in mitochondria.
SRT 1460 (CAS 925432-73-1) References
- Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. | Milne, JC., et al. 2007. Nature. 450: 712-6. PMID: 18046409
- SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. | Pacholec, M., et al. 2010. J Biol Chem. 285: 8340-51. PMID: 20061378
- SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator. | Dai, H., et al. 2010. J Biol Chem. 285: 32695-32703. PMID: 20702418
- A pharmacological review on SIRT 1 and SIRT 2 proteins, activators, and inhibitors: Call for further research. | Nandave, M., et al. 2023. Int J Biol Macromol. 242: 124581. PMID: 37105251
- Puerarin suppresses macrophage M1 polarization to alleviate renal inflammatory injury through antagonizing TLR4/MyD88-mediated NF-κB p65 and JNK/FoxO1 activation. | Hu, Z., et al. 2024. Phytomedicine. 132: 155813. PMID: 38905846
Activator of:
Sir2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SRT 1460, 1 mg | sc-474552 | 1 mg | $300.00 | |||
SRT 1460, 250 mg | sc-474552A | 250 mg | $1150.00 |