SIMPL Inhibitors
SIMPL inhibitors are a class of chemical compounds that specifically target and block the activity of the signaling molecule SIMPL (Signaling Molecule that Associates with TNF Receptor-Associated Factor 2). SIMPL is known to play a key role in modulating the nuclear factor-kappa B (NF-κB) signaling pathway, which is critical for regulating immune responses, inflammation, and cellular survival. SIMPL interacts with TNF receptor-associated factor 2 (TRAF2), acting as a co-regulator that enhances the NF-κB pathway's activation in response to external stimuli, such as tumor necrosis factor-alpha (TNF-α). By influencing the communication between TNF receptors and downstream signaling components, SIMPL contributes to the proper functioning of NF-κB-dependent transcriptional responses. Inhibitors of SIMPL are designed to disrupt its interaction with TRAF2 or other proteins involved in this pathway, thereby modulating its role in the signaling cascade.
The development of SIMPL inhibitors involves a detailed study of the structural properties of the protein, focusing on regions critical for its interaction with TRAF2 and other molecular partners. Structural biology techniques such as X-ray crystallography, molecular docking, and computational modeling are used to identify potential binding pockets and interaction domains that are essential for SIMPL's function. Once these sites are identified, inhibitors are designed to specifically block these interactions, preventing SIMPL from effectively participating in NF-κB signaling. These inhibitors are tested through various biochemical assays to evaluate their binding affinity, specificity, and ability to modulate the NF-κB pathway. By inhibiting SIMPL, researchers can better understand its contribution to cellular signaling processes and the regulation of key pathways such as immune responses and inflammation. Studying SIMPL inhibitors sheds light on the intricate molecular mechanisms that control NF-κB activity and how proteins like SIMPL fine-tune these essential cellular functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
An inhibitor of NF-κB activation. BAY 11-7082 could indirectly influence SIMPL by inhibiting NF-κB, thereby affecting pathways where SIMPL is involved. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $214.00 $257.00 $1775.00 $2003.00 | 34 | |
Blocks NF-κB nuclear translocation. JSH-23 could indirectly impact SIMPL activity by blocking NF-κB from entering the nucleus, potentially affecting SIMPL-mediated signaling. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
An NF-κB inhibitor found in cruciferous vegetables. Sulforaphane might indirectly affect SIMPL activity through its influence on NF-κB signaling pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A compound in turmeric with NF-κB inhibitory properties. Curcumin could indirectly influence SIMPL by modulating NF-κB activation and related signaling pathways. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Inhibits NF-κB activation and is also known for its anti-inflammatory properties. Parthenolide could indirectly affect SIMPL function by altering NF-κB-mediated signaling. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $33.00 $64.00 | 11 | |
An antioxidant that inhibits NF-κB activation. PDTC could indirectly influence SIMPL activity by modulating NF-κB signaling. | ||||||
Anakinra | 143090-92-0 | sc-507486 | 10 mg | $811.00 | ||
An IL-1 receptor antagonist, potentially affecting NF-κB signaling. Anakinra could indirectly impact SIMPL function by modulating inflammatory pathways that involve NF-κB activation. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Modulates TNF-alpha production and NF-κB activation. Thalidomide could indirectly affect SIMPL activity by altering TNF-mediated responses and associated NF-κB signaling. | ||||||
IKK-2 Inhibitor IV | 507475-17-4 | sc-203083 | 500 µg | $133.00 | 12 | |
An IKK-2 inhibitor, directly affecting NF-κB activation. TPCA-1 could indirectly influence SIMPL activity by targeting the NF-κB signaling pathway. | ||||||