Date published: 2026-2-14

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SHISA3 Inhibitors

The SHISA3 protein is a part of the SHISA family, which is known for its role in modulating cellular processes, especially those related to developmental signaling pathways. SHISA3, in particular, has been recognized for its involvement in the regulation of various signaling events that steer cellular growth, differentiation, and other fundamental physiological processes. This protein operates by interacting with other molecular entities within the cell, thus ensuring that signaling cascades are finely tuned and appropriately timed. Given the paramount significance of cellular signaling in the overall health and functionality of organisms, it's no surprise that aberrations or dysfunctions in proteins like SHISA3 can have profound implications, leading to a spectrum of cellular anomalies.

In this context, SHISA3 inhibitors have emerged as compounds that specifically target and modulate the activity of SHISA3. These inhibitors are meticulously designed to bind to SHISA3, thereby affecting its ability to regulate cellular signaling. The direct interaction between the inhibitor and SHISA3 can either enhance or suppress the protein's function, depending on the desired outcome and the nature of the inhibitor. The molecular design of such inhibitors often requires intricate understanding and sophisticated tools, as achieving specificity and avoiding off-target interactions are of utmost importance. In a research setting, these inhibitors can be invaluable, allowing scientists to dissect the nuanced roles of SHISA3 in cellular signaling and to understand its interplay with other cellular components. The development and study of SHISA3 inhibitors is an evolving field, and as our understanding of this protein deepens, the sophistication and efficacy of its inhibitors are likely to increase correspondingly.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

XAV939

284028-89-3sc-296704
sc-296704A
sc-296704B
1 mg
5 mg
50 mg
$36.00
$117.00
$525.00
26
(1)

XAV-939 is a Wnt pathway inhibitor that targets β-catenin. Since SHISA3 inhibits the Wnt pathway, compounds like XAV-939 might modulate SHISA3 expression as part of a feedback mechanism.

IWR-1-endo

1127442-82-3sc-295215
sc-295215A
5 mg
10 mg
$82.00
$135.00
19
(1)

IWR-1 stabilizes the Axin complex, inhibiting Wnt signaling. Given SHISA3's regulatory role in this pathway, IWR-1 may indirectly impact SHISA3 expression.

JW 55

664993-53-7sc-364517
sc-364517A
10 mg
50 mg
$172.00
$726.00
(0)

JW55 is another inhibitor of the Wnt/β-catenin pathway. Its modulation of the pathway could influence the expression or function of SHISA3.

KY02111

1118807-13-8sc-397043
sc-397043A
5 mg
25 mg
$79.00
$336.00
(0)

KY02111 promotes degradation of β-catenin. This could indirectly impact the levels or activity of SHISA3 given its involvement in Wnt signaling.

LGK 974

1243244-14-5sc-489380
sc-489380A
5 mg
50 mg
$359.00
$1295.00
2
(0)

LGK-974 is a Wnt signaling pathway inhibitor. Its actions on this pathway may indirectly influence SHISA3 expression.

β-Catenin/Tcf Inhibitor, FH535

108409-83-2sc-221398
sc-221398A
10 mg
50 mg
$182.00
$374.00
7
(1)

FH535 is an inhibitor of both the Wnt/β-catenin and PPAR signaling pathways. It could potentially impact SHISA3 expression due to its effect on Wnt signaling.

Sulindac

38194-50-2sc-202823
sc-202823A
sc-202823B
1 g
5 g
10 g
$32.00
$86.00
$150.00
3
(1)

Sulindac has been observed to inhibit the Wnt pathway by inducing the degradation of β-catenin. This could influence SHISA3 expression.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

Quercetin, a flavonoid, has been found to inhibit the Wnt pathway. Its potential effects on SHISA3 may be due to this pathway modulation.

PRI-724

1422253-38-0sc-507535
25 mg
$260.00
(0)

PRI-724 is a selective inhibitor of the interaction between β-catenin and its coactivator CBP. Its influence on the Wnt pathway could affect SHISA3 expression.

Wnt-C59

1243243-89-1sc-475634
sc-475634A
sc-475634B
5 mg
10 mg
50 mg
$214.00
$326.00
$1275.00
1
(0)

Wnt-C59 is a PORCN inhibitor in the Wnt pathway. Its effects on this pathway might have repercussions on SHISA3 expression.