The SHISA3 protein is a part of the SHISA family, which is known for its role in modulating cellular processes, especially those related to developmental signaling pathways. SHISA3, in particular, has been recognized for its involvement in the regulation of various signaling events that steer cellular growth, differentiation, and other fundamental physiological processes. This protein operates by interacting with other molecular entities within the cell, thus ensuring that signaling cascades are finely tuned and appropriately timed. Given the paramount significance of cellular signaling in the overall health and functionality of organisms, it's no surprise that aberrations or dysfunctions in proteins like SHISA3 can have profound implications, leading to a spectrum of cellular anomalies.
In this context, SHISA3 inhibitors have emerged as compounds that specifically target and modulate the activity of SHISA3. These inhibitors are meticulously designed to bind to SHISA3, thereby affecting its ability to regulate cellular signaling. The direct interaction between the inhibitor and SHISA3 can either enhance or suppress the protein's function, depending on the desired outcome and the nature of the inhibitor. The molecular design of such inhibitors often requires intricate understanding and sophisticated tools, as achieving specificity and avoiding off-target interactions are of utmost importance. In a research setting, these inhibitors can be invaluable, allowing scientists to dissect the nuanced roles of SHISA3 in cellular signaling and to understand its interplay with other cellular components. The development and study of SHISA3 inhibitors is an evolving field, and as our understanding of this protein deepens, the sophistication and efficacy of its inhibitors are likely to increase correspondingly.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
XAV-939 is a Wnt pathway inhibitor that targets β-catenin. Since SHISA3 inhibits the Wnt pathway, compounds like XAV-939 might modulate SHISA3 expression as part of a feedback mechanism. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
IWR-1 stabilizes the Axin complex, inhibiting Wnt signaling. Given SHISA3's regulatory role in this pathway, IWR-1 may indirectly impact SHISA3 expression. | ||||||
JW 55 | 664993-53-7 | sc-364517 sc-364517A | 10 mg 50 mg | $172.00 $726.00 | ||
JW55 is another inhibitor of the Wnt/β-catenin pathway. Its modulation of the pathway could influence the expression or function of SHISA3. | ||||||
KY02111 | 1118807-13-8 | sc-397043 sc-397043A | 5 mg 25 mg | $79.00 $336.00 | ||
KY02111 promotes degradation of β-catenin. This could indirectly impact the levels or activity of SHISA3 given its involvement in Wnt signaling. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $359.00 $1295.00 | 2 | |
LGK-974 is a Wnt signaling pathway inhibitor. Its actions on this pathway may indirectly influence SHISA3 expression. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $182.00 $374.00 | 7 | |
FH535 is an inhibitor of both the Wnt/β-catenin and PPAR signaling pathways. It could potentially impact SHISA3 expression due to its effect on Wnt signaling. | ||||||
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $32.00 $86.00 $150.00 | 3 | |
Sulindac has been observed to inhibit the Wnt pathway by inducing the degradation of β-catenin. This could influence SHISA3 expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, has been found to inhibit the Wnt pathway. Its potential effects on SHISA3 may be due to this pathway modulation. | ||||||
PRI-724 | 1422253-38-0 | sc-507535 | 25 mg | $260.00 | ||
PRI-724 is a selective inhibitor of the interaction between β-catenin and its coactivator CBP. Its influence on the Wnt pathway could affect SHISA3 expression. | ||||||
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $214.00 $326.00 $1275.00 | 1 | |
Wnt-C59 is a PORCN inhibitor in the Wnt pathway. Its effects on this pathway might have repercussions on SHISA3 expression. | ||||||