She Activators
She Activators encompass a range of chemical compounds that facilitate the enhancement of She's functional role within cellular signaling pathways. For example, Forskolin, through its capacity to raise intracellular cAMP levels, indirectly encourages She's activity by promoting PKA-related phosphorylation events that She is implicated in. PMA, by activating PKC, might phosphorylate proteins that interact with She, thus strengthening its involvement in growth and differentiation signals. Similarly, Ionomycin and A23187, both calcium ionophores, elevate intracellular calcium levels, which can activate calcium-sensitive signaling molecules that enhance She's activity in these pathways. Sphingosine-1-phosphate, by engaging its G protein-coupled receptors, could initiate She activation in pathways pertinent to cell movement and vascular development.
Further, compounds like LY294002 and U0126, which inhibit PI3K and MEK1/2 respectively, can reduce Akt and ERK pathway activity, thereby relieving inhibitory feedback on pathways where She is active, leading to its enhanced functional role. SB203580's selective inhibition of p38 MAPK could similarly shift signaling dynamics to favor She activation in response to cellular stress. Thapsigargin, by disrupting calcium homeostasis, can indirectly potentiate She's involvement in calcium-dependent signaling.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin serves as an activator of adenylate cyclase, which increases intracellular cAMP levels. This rise in cAMP can lead to the activation of PKA (protein kinase A), which has been shown to phosphorylate and thus enhance the activity of She by facilitating its role in downstream signaling events. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of protein kinase C (PKC). PKC can phosphorylate a plethora of proteins, including those that interact with She, leading to an enhancement of She’s role in modulating cellular growth and differentiation signaling pathways. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-sensitive signaling molecules that interact with She, thereby indirectly enhancing She’s activity in calcium-dependent pathways. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P functions by binding to its G protein-coupled receptors, which can initiate downstream signaling cascades that involve She activation, especially in pathways related to cell migration and angiogenesis. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to inhibit certain types of kinases, which can reduce competitive inhibition of signaling pathways where She plays a regulatory role, indirectly increasing She’s functional activity in these pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that by inhibiting PI3K can lead to diminished Akt signaling, which may relieve negative feedback on pathways involving She, thereby enhancing She’s functional activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK, and by inhibiting p38, it can modulate other MAPK-related pathways positively influencing the functional activity of She in stress response signaling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor which leads to an increase in cytosolic calcium levels, indirectly promoting She’s activity by activating calcium-dependent signaling pathways that She may be involved in. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor which may enhance She’s activity by reducing competitive phosphorylation events, allowing for enhanced She signaling in pathways where tyrosine kinase activity is usually high. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is another calcium ionophore that increases intracellular calcium, much like ionomycin, and can indirectly increase She’s activity through calcium-sensitive pathways that She modulates. | ||||||