Shc Activators
Shc activators represent a distinctive chemical class within the realm of molecular biology and cellular signaling. These compounds are primarily characterized by their ability to modulate the activity of Shc (Src homology and collagen homology) proteins, which serve as critical mediators in various signal transduction pathways within the cell. Shc proteins play a pivotal role in relaying extracellular signals, such as growth factors and cytokines, to intracellular targets, thereby regulating essential cellular processes like proliferation, differentiation, and survival.
At the molecular level, Shc activators typically function by promoting the phosphorylation of Shc proteins, particularly tyrosine phosphorylation, which serves as a crucial event in initiating downstream signaling cascades. This phosphorylation event enables Shc proteins to interact with various effector molecules, including kinases and adaptor proteins, thus propagating the extracellular signal further into the cell. The activation of Shc proteins can result in the activation of several major intracellular pathways, including the Ras-MAPK pathway and the PI3K-Akt pathway, both of which are pivotal in regulating cell growth, differentiation, and survival. Consequently, Shc activators represent a valuable tool in the study of cellular signaling networks and provide insights into the intricate mechanisms governing cell behavior and fate. They contribute significantly to our understanding of basic cellular biology and signal transduction processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone, a thiazolidinedione, can activate PPAR-γ, potentially influencing intracellular signaling pathways, and may alter the expression of Shc proteins as part of its effects on glucose metabolism. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a polyphenol from turmeric, can modulate various signaling pathways, and has the potential to influence the expression of Shc proteins, although the exact mechanism may be complex and context-dependent. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol found in grapes, can activate sirtuins and modulate various signaling pathways, potentially influencing Shc protein expression linked to cellular stress responses and aging. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Exposure to sodium arsenite can induce oxidative stress, potentially activating signaling pathways that influence Shc protein expression as part of the cellular stress response. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid found in many fruits and vegetables, can modulate various signaling pathways, and may have the potential to influence the expression of Shc proteins. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine can modulate intracellular signaling pathways through its action on adenosine receptors, potentially influencing the expression of Shc proteins in various cellular contexts. | ||||||
Vitamin A | 68-26-8 | sc-280187 sc-280187A | 1 g 10 g | $385.00 $2654.00 | ||
Retinol, a form of vitamin A, can be converted to retinoic acid and modulate gene expression, potentially influencing the expression of Shc proteins involved in cellular differentiation processes. | ||||||
DL-α-Tocopherol | 10191-41-0 | sc-294383 sc-294383A sc-294383B sc-294383C | 5 g 25 g 100 g 500 g | $26.00 $52.00 $124.00 $326.00 | 3 | |
Vitamin E has antioxidant properties, potentially modulating cellular signaling pathways and influencing the expression of Shc proteins as part of the cellular response to oxidative stress. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
BPA can interact with estrogen receptors, potentially influencing signaling pathways and possibly altering the expression of Shc proteins in a manner dependent on the cellular context. | ||||||