SH3BGR Activators
SH3BGR activators belong to a specialized class of chemical compounds with the primary function of modulating the activity of the SH3BGRL (SH3 domain-binding glutamic acid-rich-like) protein. The SH3BGRL protein plays a pivotal role in various intracellular signaling pathways, especially those associated with cell growth, proliferation, and survival. Activators of SH3BGR are designed to enhance the protein's function and influence downstream cellular processes without targeting a specific disease or medical condition. These compounds have garnered significant attention in the field of cellular biology and molecular research, as they offer a valuable tool for investigating the fundamental mechanisms governing cell behavior and protein interactions.
SH3BGR activators work by binding to the SH3BGRL protein, inducing conformational changes that can result in altered protein-protein interactions or signaling cascades. The activation of SH3BGRL is known to impact multiple cellular processes, such as apoptosis, cell adhesion, and cytoskeleton organization, making these activators essential in elucidating the intricate web of intracellular signaling events. Researchers have employed these chemical entities in numerous studies to unravel the intricacies of various cellular processes and identify targets for drug development. I
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates signaling pathways, potentially increasing SH3BGR activation. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Can directly or indirectly activate SH3BGR through the PI3K/AKT signaling pathway. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
A phosphodiesterase inhibitor that may indirectly increase SH3BGR activation by modulating cAMP signaling. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase and increases cAMP levels, potentially increasing SH3BGR activation directly or indirectly. | ||||||
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $343.00 $1642.00 | 20 | |
An inhibitor of Protein kinase C (PKC), which can indirectly activate SH3BGR through downstream pathways. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
A protein tyrosine phosphatase inhibitor with implications for increasing SH3BGR activation, either directly or indirectly. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor, potentially increasing SH3BGR activation through the mTOR signaling pathway, either directly or indirectly. | ||||||