SH2D5 Activators
SH2 domain-containing protein 5 (SH2D5) activators encompass a range of chemical compounds that facilitate the protein's functional activity by engaging with various specific signaling pathways. Forskolin, for instance, raises the intracellular levels of cAMP, which indirectly augments SH2D5 activity by activating protein kinase A (PKA). PKA can then phosphorylate proteins that may associate with SH2D5, thus amplifying its signaling capacity. Similarly, Epigallocatechin gallate, a kinase inhibitor, potentially improves SH2D5's function by lowering the competitive inhibition of SH2D5's binding partners. This action could make more binding partners available to SH2D5, thereby enhancing its functional role in signaling pathways.
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which may phosphorylate downstream targets that interact with SH2D5, increasing its activity. Inhibition of phosphatidylinositol 3-kinase (PI3K) by LY294002 and Wortmannin might also indirectly enhance SH2D5's activity by modulating the dynamics of the AKT signaling pathway.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Increases intracellular cAMP levels, leading to the activation of PKA, which could phosphorylate SH2D5 enhancing its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Inhibits certain kinases, potentially reducing competition for SH2D5 binding partners, thus enhancing its signaling capacity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates PKC, which may phosphorylate downstream targets that interact with SH2D5, enhancing its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Inhibits PI3K, altering downstream AKT signaling which could create a favorable context for SH2D5-mediated signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A PI3K inhibitor that, like LY294002, could indirectly enhance SH2D5 activity by modulating AKT pathway dynamics. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
Inhibits p38 MAPK, which may lead to a signaling environment that indirectly enhances SH2D5 activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Increases intracellular calcium levels, possibly inducing calcium-dependent phosphorylation events that enhance SH2D5 function. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A broad-spectrum kinase inhibitor that could lead to selective activation of pathways involving SH2D5. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Through modulation of lipid signaling, it could potentiate pathways in which SH2D5 is involved. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
A SERCA pump inhibitor that elevates cytosolic calcium levels, potentially enhancing SH2D5-related signaling. | ||||||