SGS3 Activators
SGS3 (Suppressor of Gene Silencing 3) is a protein that plays a significant role in the RNA silencing pathway in plants. RNA silencing is a crucial regulatory mechanism in eukaryotic organisms that controls gene expression and defends against viruses. It involves small RNAs, such as small interfering RNAs (siRNAs) and microRNAs (miRNAs), which guide the silencing machinery to specific RNA targets to block their translation or to degrade them.SGS3 was first identified in Arabidopsis thaliana, a model organism for plant biology research. It is involved in the post-transcriptional gene silencing (PTGS) pathway, particularly in the biogenesis of trans-acting siRNAs (ta-siRNAs). These ta-siRNAs are a class of small RNAs that mediate gene silencing at the post-transcriptional level and are involved in a variety of developmental processes and stress responses in plants.
The SGS3 protein interacts with RNA-DEPENDENT RNA POLYMERASE 6 (RDR6) and DICER-LIKE 4 (DCL4), two other key components in the RNA silencing pathway. This interaction is essential for the production of double-stranded RNA, which is then processed into ta-siRNAs. SGS3 is unique in that it binds to single-stranded RNA featuring a 5' overhang, a feature characteristic of the precursors of ta-siRNAs.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gibberellic acid | 77-06-5 | sc-257556 sc-257556A sc-257556B sc-257556C | 500 mg 1 g 5 g 25 g | $47.00 $63.00 $145.00 $515.00 | 2 | |
Gibberellic Acid, another plant hormone, influences various aspects of plant development and could indirectly affect RNA silencing mechanisms where SGS3 is involved. | ||||||
Kinetin | 525-79-1 | sc-207780 sc-207780A | 1 g 5 g | $38.00 $48.00 | ||
Kinetin, a type of cytokinin, is involved in plant growth and development and might impact processes related to RNA silencing and thus, potentially, SGS3 activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, could indirectly influence RNA silencing pathways and mechanisms potentially related to SGS3 in plant models. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
Zebularine, another DNA methyltransferase inhibitor, may affect epigenetic regulation and thereby have an indirect impact on RNA silencing processes involving SGS3. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA, an HDAC inhibitor, primarily used in human cells, could offer insights into epigenetic regulation mechanisms that might be analogous to those involving SGS3 in plants. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108, a DNA methyltransferase inhibitor, could potentially influence epigenetic mechanisms and thereby impact RNA silencing processes related to SGS3. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
S-Adenosyl Methionine, involved in methylation processes, might have an indirect effect on epigenetic regulation and RNA silencing pathways relevant to SGS3. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, an HDAC inhibitor, may affect chromatin remodeling and gene expression, potentially influencing RNA silencing mechanisms where SGS3 plays a role. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate, another HDAC inhibitor, could indirectly impact chromatin structure and gene expression, potentially affecting RNA silencing processes involving SGS3. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
BIX 01294, a G9a histone methyltransferase inhibitor, might affect chromatin structure and gene expression, potentially impacting SGS3 functionality in RNA silencing. | ||||||