SGLT-3 Inhibitors
SGLT-3 inhibitors belong to a class of chemical compounds designed to target and modulate the activity of the Sodium-Glucose Transporter 3 (SGLT-3) protein. SGLT-3 is a member of the SGLT family of transport proteins that are responsible for transporting glucose and sodium ions across cell membranes. These transporters play a critical role in maintaining glucose homeostasis in the body by reabsorbing glucose from the renal tubules in the kidneys. While SGLT-1 and SGLT-2 are well-studied members of this family and have been targeted for purposes, the exact function and significance of SGLT-3 are still areas of active research. Inhibitors of SGLT-3 are developed to interact with this transporter, disrupting its function and affecting glucose and sodium transport processes within cells.
SGLT-3 inhibitors are typically designed as small molecules or compounds that can bind to SGLT-3, interfering with its ability to transport glucose and sodium ions across cell membranes. By doing so, these inhibitors may influence glucose reabsorption in the kidneys or other cellular processes that depend on SGLT-3 activity. Research into SGLT-3 inhibitors is essential for unraveling the precise role of SGLT-3 in glucose homeostasis and sodium transport, shedding light on its implications in metabolic regulation and renal function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $63.00 $250.00 | 13 | |
Phloretin is a dihydrochalcone found in apple leaves that can inhibit various glucose transporters by interfering with their function, potentially affecting the cellular mechanisms regulating SGLT-3 expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties and has been shown to modulate the expression of various proteins, which may include transporters like SGLT-3. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is an isoflavone found in soy products that acts as a tyrosine kinase inhibitor and may impact protein expression by influencing signaling pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is the principal curcuminoid of turmeric and may affect the expression of proteins by modulating transcription factors and signaling pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a stilbenoid with various biological activities and has been shown to influence gene expression, possibly including that of SGLT-3. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, the major catechin in green tea, has been reported to affect gene expression, which could theoretically include genes encoding transporters like SGLT-3. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $97.00 $212.00 $500.00 | 11 | |
Kaempferol is a natural flavonol that may modulate the expression of several proteins by affecting transcriptional activity. | ||||||
Myricetin | 529-44-2 | sc-203147 sc-203147A sc-203147B sc-203147C sc-203147D | 25 mg 100 mg 1 g 25 g 100 g | $95.00 $184.00 $255.00 $500.00 $1002.00 | 3 | |
Myricetin is a flavonoid compound that may have regulatory effects on protein expression through its interactions with cellular signaling pathways. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin is a flavonoid found in many plants and has been implicated in the regulation of gene expression, which could extend to proteins like SGLT-3. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $37.00 | 13 | |
Chrysin is a flavone found in honey and propolis with biological activities that suggest it can modulate protein expression through various pathways. | ||||||