SFI1 Activators
SFI1, or spindle assembly checkpoint factor 1, is a protein that in humans is encoded by the SFI1 gene. This protein plays a critical role in the spindle checkpoint function, which ensures that all chromosomes are properly attached to the spindle microtubules before the cell enters anaphase during cell division. This helps prevent errors in chromosome segregation, which can lead to genetic instability and diseases. The protein itself is localized to the centrosome in interphase cells and to the poles of the mitotic spindle during cell division.
Centrin is a calcium-binding protein that is a member of the EF-hand superfamily, named for a helix-loop-helix structural domain found in a large family of calcium-binding proteins. Centrins play crucial roles in various cellular processes, including centrosome duplication, DNA repair, and cilia or flagella function. In the context of the SFI1 protein, centrin binding is critical for the proper function of the spindle checkpoint. Any molecule that acts as an activator for SFI1 or centrin would likely be involved in the regulation of these proteins' activities or their interactions with other cellular components. Activation could take many forms, such as promoting the proteins' binding to other molecules, enhancing their activity, or altering their location within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules, and could potentially stimulate SFI1 activity indirectly by enhancing the stability of microtubules, a process where SFI1 is involved. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine disrupts microtubule assembly, potentially promoting SFI1 activity indirectly by altering microtubule dynamics - a process in which SFI1 is involved. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule dynamics, potentially stimulating SFI1 activity indirectly by modifying the stability of microtubules, a process where SFI1 is involved. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine inhibits microtubule polymerization, potentially triggering SFI1 activity indirectly by modulating the formation of the mitotic spindle, a process where SFI1 plays a key role. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol inhibits the kinesin Eg5, potentially promoting SFI1 activity indirectly by altering spindle dynamics, a process where SFI1 is known to interact with spindle-associated proteins. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM447439 inhibits Aurora kinases, potentially spurring SFI1 activity indirectly by modifying stages of mitosis, a process where SFI1 plays a role. | ||||||
BI6727 | 755038-65-4 | sc-364432 sc-364432A sc-364432B sc-364432C sc-364432D | 5 mg 50 mg 100 mg 500 mg 1 g | $150.00 $1050.00 $1665.00 $3329.00 $4382.00 | 1 | |
Volasertib inhibits Polo-like kinase 1 (PLK1), potentially promoting SFI1 activity indirectly by modifying the progression of the cell cycle, one of the processes where SFI1 plays a role. | ||||||
RO-3306 | 872573-93-8 | sc-358700 sc-358700A sc-358700B | 1 mg 5 mg 25 mg | $66.00 $163.00 $326.00 | 37 | |
RO-3306 is an inhibitor of Cyclin-dependent kinase 1 (CDK1), potentially stimulating SFI1 activity indirectly by altering the cell cycle, a process where SFI1 is involved. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin inhibits phosphoinositide 3-kinases (PI3K), potentially stimulating SFI1 activity indirectly by altering PI3K signaling, which regulates cell growth and division, processes where SFI1 is involved. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, potentially triggering SFI1 activity indirectly by modifying the processes of cell growth and proliferation, where SFI1 is involved. | ||||||