Separase Inhibitors
Separase inhibitors are a class of chemical compounds that play a critical role in the regulation of cell division and the maintenance of genomic integrity. These inhibitors are specifically designed to target a key enzyme known as separase, which is involved in the separation of sister chromatids during cell division, a process known as mitosis. Separase is an essential component of the cell cycle machinery, and its activity is tightly controlled to ensure accurate chromosome segregation. In normal cell division, separase is activated at a precise moment, allowing it to cleave a protein called cohesin, which holds sister chromatids together. This cleavage of cohesin allows the chromatids to separate and move to opposite poles of the dividing cell, ensuring that each daughter cell receives the correct number of chromosomes.
The development of separase inhibitors has provided researchers with a powerful tool to investigate the molecular mechanisms underlying cell division. By inhibiting separase activity, scientists can gain insights into how this enzyme contributes to chromosome segregation and cell cycle progression. Additionally, separase inhibitors have potential applications in the field of cancer research, as the dysregulation of separase activity is associated with aneuploidy, a condition characterized by an abnormal number of chromosomes in cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Interferes with microtubule function, potentially inhibiting separase indirectly by disrupting mitotic spindle formation and thus preventing the activation of separase. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Stabilizes the DNA topoisomerase I-DNA complex, inducing DNA damage and potentially leading to the inhibition of separase indirectly through cell cycle arrest. | ||||||
Everolimus | 159351-69-6 | sc-218452 sc-218452A | 5 mg 50 mg | $131.00 $651.00 | 7 | |
An mTOR inhibitor that can lead to cell cycle arrest, potentially reducing separase activity by preventing cells from reaching metaphase. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Binds to tubulin and inhibits microtubule polymerization, potentially affecting separase activation by interfering with spindle assembly. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
Inhibits DNA polymerase and may lead to cell cycle arrest, indirectly affecting separase activity by preventing entry into mitosis. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Crosslinks DNA, potentially causing cell cycle arrest and indirectly inhibiting separase by preventing chromatid separation. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Causes DNA cleavage and can induce cell cycle arrest, potentially affecting separase activity indirectly by preventing proper chromosome segregation. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Inhibits DNA topoisomerase II, leading to DNA damage and potentially inhibiting separase indirectly through cell cycle arrest. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
A cyclin-dependent kinase inhibitor that can arrest the cell cycle, potentially reducing separase activity by preventing cells from entering mitosis. | ||||||