sentan Inhibitors
Chemical inhibitors of Sentan can interfere with its function in various ways, primarily through the disruption of signaling pathways and cellular processes crucial for ciliogenesis. LY294002 and Wortmannin, both phosphoinositide 3-kinases (PI3K) inhibitors, can impair Sentan's role by altering the dynamics of membrane phospholipids, crucial for Sentan's function in membrane curvature and ciliary formation. Spautin-1, which promotes the degradation of PI3K, similarly can lead to the functional inhibition of Sentan by disturbing the PI3K signaling pathways. On a different pathway, PD98059 and U0126, as inhibitors of mitogen-activated protein kinase kinase (MEK), can inhibit Sentan by preventing the activation of downstream signaling that is required for the proper development and function of cilia. This is further complicated by the involvement of the mTOR pathway, where Rapamycin, an mTOR inhibitor, can indirectly affect Sentan function related to cell growth and protein synthesis for ciliary assembly.
Moreover, Sentan's role in ciliogenesis is closely tied to vesicular trafficking and the actin cytoskeleton. Bafilomycin A1, a V-ATPase inhibitor, can disrupt endosomal acidification, which is vital for vesicle-mediated transport processes essential for ciliary function where Sentan is active. Cytochalasin D and Latrunculin A, which disrupt actin polymerization, can inhibit Sentan function by impairing ciliary vesicle trafficking and assembly. Dynasore, a GTPase inhibitor that blocks dynamin activity, can also inhibit Sentan by hindering vesicular release and trafficking. Furthermore, 3-Methyladenine, by inhibiting autophagy through its action on PI3K, can affect cellular remodeling and trafficking processes crucial for ciliary structures. Lastly, Mitoxantrone, an inhibitor of topoisomerase II, can affect Sentan by altering cell cycle and cellular division processes that are integral to the formation of cilia.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3Ks). Sentan is implicated in membrane curvature and ciliogenesis. Inhibition of PI3Ks by LY294002 could disrupt membrane phospholipid dynamics, thereby functionally inhibiting Sentan's role in membrane shaping processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another potent PI3K inhibitor. Similar to LY294002, Wortmannin's inhibition of PI3K activity could lead to a functional inhibition of Sentan by interfering with the phospholipid signaling that is crucial for Sentan's role in the formation and maintenance of cilia. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of mitogen-activated protein kinase kinase (MEK). Sentan, involved in ciliary function, could be affected by PD98059 through inhibition of the MEK/ERK pathway which is involved in cellular differentiation and may be crucial for ciliogenesis where Sentan operates. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 specifically inhibits MEK1/2. By inhibiting MEK, U0126 could functionally inhibit Sentan by preventing the activation of downstream signaling required for the development and function of cilia, where Sentan is localized. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an inhibitor of the mammalian target of rapamycin (mTOR). Sentan, by being associated with ciliary structure and function, could be indirectly inhibited by Rapamycin through the mTOR pathway, which is instrumental in cell growth and protein synthesis related to ciliary assembly. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $165.00 | ||
Spautin-1 is known to promote the degradation of PI3K. By promoting the degradation of PI3K, Spautin-1 could lead to functional inhibition of Sentan by disrupting the PI3K signaling pathways that are potentially involved in Sentan's function in cilia. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1 is a V-ATPase inhibitor that can disrupt endosomal acidification. Given that Sentan is involved in vesicular trafficking related to ciliogenesis, Bafilomycin A1 could inhibit Sentan function by impairing vesicle-mediated transport processes essential for ciliary function. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $56.00 $256.00 | 113 | |
3-Methyladenine is an inhibitor of autophagy through its action on PI3K. By inhibiting autophagy, 3-Methyladenine could functionally inhibit Sentan by affecting cellular remodeling and trafficking processes, which are important for the maintenance of ciliary structures where Sentan acts. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D disrupts actin polymerization. Sentan's role in ciliogenesis could be functionally inhibited by Cytochalasin D, as the actin cytoskeleton is crucial for ciliary vesicle trafficking and assembly, processes that are important for Sentan's function in cilia. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore is a GTPase inhibitor that blocks dynamin's activity. Because Sentan is involved with ciliary function and structure, inhibiting dynamin with Dynasore could functionally inhibit Sentan by hindering vesicular release and trafficking crucial for ciliary assembly and maintenance. | ||||||