SEMA4G Activators
SEMA4G Activators encompass compounds that influence a variety of intracellular signaling pathways, which can lead to the enhancement of SEMA4G function. Forskolin, by elevating cAMP levels, activates PKA, which might enhance SEMA4G's role in neuronal guidance by phosphorylating downstream signaling molecules. Similarly, PMA targets PKC, which could lead to phosphorylation cascades that bolster SEMA4G-mediated axonal guidance. Compounds like IBMX and Rolipram, by inhibiting phosphodiesterase activity, augment intracellular cAMP levels and subsequently PKA activity, enhancing SEMA4G's signaling pathways indirectly.
Retinoic acid, by altering gene expression, could result in the upregulation of proteins that interact with SEMA4G, enhancing its signaling. Lithium chloride's inhibition of GSK-3 might stabilize components of SEMA4G's pathways, promoting SEMA4G-mediated neuronal guidance. Sildenafil, by increasing cGMP levels, might indirectly influence cAMP and thus PKA activity, which could phosphorylate proteins associated with SEMA4G, enhancing its signaling role.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels, which activates PKA and could phosphorylate various substrates, potentially enhancing SEMA4G signaling functions related to neuronal guidance and growth. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates PKC, leading to the phosphorylation of proteins within SEMA4G's pathways, potentially enhancing SEMA4G-mediated axonal guidance. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX increases cAMP by inhibiting phosphodiesterases, indirectly augmenting PKA activity and possibly enhancing SEMA4G signaling in neuronal cells through phosphorylation of associated proteins. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine activates adrenergic receptors, increasing cAMP and PKA activity, potentially enhancing SEMA4G function in guiding neuronal growth by phosphorylating downstream effectors. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine acts on H2 receptors to raise cAMP levels, activating PKA and potentially enhancing SEMA4G signaling in neurodevelopmental processes. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid modulates gene expression via nuclear receptors, potentially enhancing SEMA4G signaling by upregulating proteins that interact with or regulate SEMA4G. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3, potentially stabilizing proteins within SEMA4G signaling pathways and enhancing the SEMA4G-mediated axonal guidance. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits PDE4, raising cAMP levels, which could activate PKA and enhance SEMA4G activity in neuronal patterning through phosphorylation of relevant substrates. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 inhibits ROCK, potentially altering actin dynamics and enhancing SEMA4G activity as the cell adapts its cytoskeleton, which is essential for SEMA4G's role in cell migration and axon guidance. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Blebbistatin inhibits myosin II ATPase, affecting cytoskeletal tension, potentially necessitating enhanced SEMA4G activity to maintain cellular structure during neuronal development. | ||||||