SEMA4G Antibody (C-12): sc-515644

SEMA4G Antibody (C-12) is a mouse monoclonal IgM antibody that detects SEMA4G protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SEMA4G antibody (C-12) is available as a non-conjugated format. SEMA4G protein, also known as semaphorin-4G, is an 838 amino acid single-pass type I membrane protein that plays a crucial role in axon guidance, a process essential for proper development of the nervous system. SEMA4G exists in three alternatively spliced isoforms and features one immunoglobulin-like C2-type domain, a PSI domain, and a single sema domain, which are important for function in mediating cell signaling and interactions. These domains allow SEMA4G to interact with specific receptors on the surface of neurons, facilitating attraction or repulsion of axons during neural network formation. Understanding SEMA4G function is vital, as SEMA4G contributes to intricate processes of neural development and may have implications in neurodevelopmental disorders.

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SEMA4G Antibody (C-12) References:

1. Characterization and expression of sema4g, a novel member of the semaphorin gene family.  |  Li, H., et al. 1999. Mech Dev. 87: 169-73. PMID: 10495281
2. Semaphorins: contributors to structural stability of hippocampal networks?  |  Holtmaat, AJ., et al. 2002. Prog Brain Res. 138: 17-38. PMID: 12432760
3. Molecular mechanisms of axon guidance.  |  Dickson, BJ. 2002. Science. 298: 1959-64. PMID: 12471249
4. Semaphorin junction: making tracks toward neural connectivity.  |  Pasterkamp, RJ. and Kolodkin, AL. 2003. Curr Opin Neurobiol. 13: 79-89. PMID: 12593985
5. Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif.  |  Burkhardt, C., et al. 2005. FEBS Lett. 579: 3821-8. PMID: 15978582
6. Semaphorins and their receptors in lamprey CNS: Cloning, phylogenetic analysis, and developmental changes during metamorphosis.  |  Shifman, MI. and Selzer, ME. 2006. J Comp Neurol. 497: 115-32. PMID: 16680764
7. Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development.  |  Maier, V., et al. 2011. Mol Cell Neurosci. 46: 419-31. PMID: 21122816
8. The Plexin-B family and its role in cancer progression.  |  Malik, MF., et al. 2014. Histol Histopathol. 29: 151-65. PMID: 24043639
9. The miR-608 rs4919510 polymorphism may modify cancer susceptibility based on type.  |  Wu, S., et al. 2017. Tumour Biol. 39: 1010428317703819. PMID: 28653886
10. Identification of the shared gene signatures and pathways between sarcopenia and type 2 diabetes mellitus.  |  Huang, S., et al. 2022. PLoS One. 17: e0265221. PMID: 35271662
11. Variants in TPO rs2048722, PTCSC2 rs925489 and SEMA4G rs4919510 affect thyroid carcinoma susceptibility risk.  |  Shen, Z., et al. 2023. BMC Med Genomics. 16: 19. PMID: 36737753
12. Ribosomal protein L24 mediates mammalian microRNA processing in an evolutionarily conserved manner.  |  Tzur, Y., et al. 2024. Cell Mol Life Sci. 81: 55. PMID: 38261097

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SEMA4G Antibody (C-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SEMA4G Antibody (C-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SEMA4G Antibody (C-12) Specifications

Alternate Product Name: SEMA4G

Product Clone Name: C-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 26-47

Epitope Target: SEMA4G

Epitope Species: human

Product Reactivity/Detection: SEMA4G

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SEMA4G Antibody (C-12): P: Blocking Peptide