SEC14L1 Activators
SEC14L1 activators are compounds that directly or indirectly enhance the function of SEC14L1, a protein involved in the exchange of lipids between different cellular membranes. These activators function by manipulating the cellular levels of cAMP, a messenger molecule that can affect SEC14L1's lipid trafficking function. For instance, compounds like Forskolin, Isoproterenol, and Dobutamine act as potent activators of adenylyl cyclase, the enzyme responsible for generating cAMP. Once activated, adenylyl cyclase elevates the intracellular levels of cAMP, which subsequently enhances the activity of SEC14L1.
On the other hand, Albuterol, Terbutaline, and Epinephrine function as beta-2 adrenergic receptor agonists. Their action results in an increase in intracellular cAMP levels, thereby indirectly activating SEC14L1. Lastly, we have a group of phosphodiesterase inhibitors such as Theophylline, IBMX, Rolipram, Sildenafil, and Zaprinast. These compounds inhibit the degradation of cAMP, maintaining high intracellular levels, which in turn can enhance SEC14L1 function. The unifying mechanism of these diverse compounds lies in their ability to increase cAMP levels, thus promoting the lipid exchange process facilitated by SEC14L1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a potent activator of adenylyl cyclase which increases intracellular levels of cAMP. Elevated cAMP levels can enhance the SEC14L1-mediated lipid exchange between membranes, aiding in the trafficking of lipid-linked proteins. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a non-selective beta-adrenergic agonist that increases intracellular cAMP levels. The increased cAMP can activate SEC14L1, promoting the lipid exchange process. | ||||||
Dobutamine | 34368-04-2 | sc-507555 | 100 mg | $295.00 | ||
Dobutamine is a beta-1 adrenergic receptor agonist that increases cAMP levels. This can enhance SEC14L1 function in lipid trafficking. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $94.00 $141.00 | ||
Albuterol is a beta-2 adrenergic receptor agonist that leads to increased cAMP levels. This, in turn, can enhance the function of SEC14L1. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $92.00 $378.00 | 2 | |
Terbutaline is another beta-2 adrenergic receptor agonist that can increase cAMP levels, enhancing SEC14L1 activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine is a non-selective adrenergic agonist that increases intracellular cAMP levels, potentially enhancing the function of SEC14L1. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 is a prostaglandin that activates adenylate cyclase, leading to increased cAMP levels. This can enhance the function of SEC14L1. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $32.00 $85.00 | 6 | |
Theophylline is a non-selective phosphodiesterase inhibitor, leading to increased cAMP levels. This can enhance the function of SEC14L1. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor, leading to increased cAMP levels. This can enhance the function of SEC14L1. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective PDE4 inhibitor, leading to increased cAMP levels. This can enhance the function of SEC14L1. | ||||||