SEBOX Activators
SEBOX activators are chemicals that can modulate the expression or activity of the SEBOX homeobox protein, a crucial entity in coordinating gene expression during specific developmental stages. The range of chemicals that can act as activators for SEBOX span diverse biochemical mechanisms. Retinoic acid, for example, operates through the retinoic acid signaling pathway, known to collaborate with homeobox genes during certain developmental transitions. Consequently, when retinoic acid signaling undergoes modulation, homeodomain proteins such as SEBOX can see corresponding alterations in their expression.
Methylation is another pivotal regulatory mechanism in gene expression, with certain genes being silenced through this process. DNA methyltransferase like 5-Azacytidine, Decitabine, and Zebularine play a role in re-energizing the expression of such silenced genes. SEBOX expression is subdued due to methylation, these chemicals can act as activators by restoring its transcription. Furthermore, the role of histone modifications in gene expression can't be overlooked. Histone deacetylase, such as Valproic acid, Trichostatin A, Vorinostat, and MS-275, target the acetylation status of histones, leading to a more transcriptionally active chromatin conformation. SEBOX's expression is influenced by such epigenetic marks, these serve to accentuate its transcription. Similarly, compounds like BIX-01294 and UNC0638, which target histone methylation, offer another layer of regulation. Through the described chemicals, SEBOX's pivotal role in developmental gene regulation can be more deeply explored, illuminating its functional nuances in intricate developmental cascades.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can modulate retinoic acid receptors, which coordinate with homeobox genes in certain developmental stages. SEBOX, being a homeodomain protein, can have its expression affected by alterations in the retinoic acid signaling. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine inhibits DNA methyltransferase, potentially activating genes silenced by methylation. If SEBOX is repressed by methylation, 5-Azacytidine can rejuvenate its expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
A histone deacetylase inhibitor, Valproic acid can lead to an open chromatin structure. If SEBOX expression is modulated by histone acetylation, this compound can enhance its transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Similar to Valproic acid, Trichostatin A as a histone deacetylase inhibitor can boost expression of genes affected by acetylation status, potentially including SEBOX. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, by affecting multiple cellular pathways, can modulate gene expression. The homeobox genes like SEBOX can be influenced by its epigenetic actions. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Another DNA methyltransferase inhibitor, Decitabine can restore the expression of genes silenced due to methylation, potentially acting on SEBOX if it's a target of methylation. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 free base | sc-202651 | 5 mg | $148.00 | 4 | |
This is an inhibitor of G9a histone methyltransferase. If SEBOX expression is tempered by histone methylation, BIX-01294 can act as an indirect activator by altering histone methylation patterns. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
A pan-histone deacetylase inhibitor, Vorinostat can influence the transcription of genes whose expression is regulated by histone acetylation, potentially encompassing SEBOX. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $126.00 $278.00 $984.00 | 3 | |
Zebularine, as a DNA methyltransferase inhibitor, can rejuvenate the expression of genes that undergo methylation-driven silencing, possibly including SEBOX. | ||||||
Tranylcypromine | 13492-01-8 | sc-200572 sc-200572A | 1 g 5 g | $172.00 $587.00 | 5 | |
An irreversible monoamine oxidase inhibitor, Parnate has been shown to influence histone demethylation, which could affect SEBOX if its expression is modulated by histone methylation. | ||||||