SDF-4 Activators
SDF-4 activators comprise a diverse array of chemical compounds that indirectly boost the protein's functional activity through various cellular signaling cascades. Forskolin, for instance, elevates cAMP levels within cells, indirectly bolstering SDF-4's functional activity through cAMP-dependent protein kinase (PKA) pathways. PKA can then phosphorylate downstream effectors that are instrumental in SDF-4-related cellular functions. Similarly, Epigallocatechin gallate, known for its kinase inhibitory properties, may ease the inhibitory pressure on pathways that SDF-4 participates in, thus enhancing its activity. The modulation of lipid signaling by Sphingosine-1-phosphate also creates a cellular milieu conducive to the elevated activity of SDF-4 by engaging with lipid-based signaling mechanisms that SDF-4 is likely involved with.
Additionally, compounds that affect calcium signaling, such as A23187, induce an increase in intracellular calcium levels, leading to the activation of calcium-dependent pathways that can augment SDF-4 activity. In the context of kinase inhibition, Staurosporine, despite its broad-spectrum profile, may selectively relieve certain inhibitory pressures exerted on SDF-4, resulting in its functional elevation. Meanwhile, LY294002 and U0126, as inhibitors of PI3K and MEK respectively, could shift the balance of cellular signaling in favor of pathways that lead to SDF-4 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, which can enhance SDF-4 activity through cAMP-dependent pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX prevents cAMP degradation, synergistically working with Forskolin to amplify SDF-4 activation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This compound inhibits certain kinases, potentially reducing negative regulatory influences on SDF-4 activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
As a PKC activator, PMA can initiate downstream effects that lead to the enhanced functional activity of SDF-4. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
This PI3K inhibitor can shift cellular signaling pathways to enhance SDF-4 activity indirectly. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 elevates intracellular calcium, which can activate calcium-dependent pathways enhancing SDF-4 activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Modulating lipid signaling pathways, this compound can enhance pathways that SDF-4 is involved in. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
By inhibiting MEK, PD98059 can promote the activation of alternative pathways that can enhance SDF-4 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
This p38 MAPK inhibitor may indirectly enhance SDF-4 activity by modulating related stress response pathways. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Although a broad-spectrum kinase inhibitor, it can selectively enhance SDF-4 activity by specific kinase inhibition. | ||||||