SDF-2L1 Activators
SDF-2L1 activators are chemical compounds that, through their direct or indirect interactions with the cyclic AMP (cAMP) pathway, can enhance the functional activity of SDF-2L1. This protein is known to be activated via the cAMP-PKA (Protein Kinase A) pathway, and by influencing this pathway, these compounds can lead to enhanced functional activity of SDF-2L1. Forskolin, PGE2, Epinephrine, Isoproterenol, Dobutamine, Terbutaline, Albuterol, and NKH477 are activators of adenylyl cyclase, the enzyme responsible for cAMP production. By activating adenylyl cyclase, these compounds lead to an increase in cAMP levels in cells. Elevated cAMP can activate PKA, which can then enhance the functional activity of SDF-2L1. L-858051, an EGFR inhibitor, indirectly affects the cAMP-PKA pathway by reducing the negative regulation by EGFR, leading toincreased cAMP levels and enhanced SDF-2L1 activity.
On the other hand, IBMX, Rolipram, and Cilostamide function as inhibitors of phosphodiesterases (PDEs), the enzymes responsible for breaking down cAMP. They work by inhibiting PDEs, thereby increasing cAMP levels in cells and indirectly enhancing SDF-2L1 activity via the cAMP-PKA pathway. IBMX is a non-specific inhibitor of PDEs, whereas Rolipram selectively inhibits PDE4, and Cilostamide selectively inhibits PDE3. Although these compounds do not directly act on SDF-2L1, their influence on the cAMP-PKA pathway can lead to enhanced functional activity of SDF-2L1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a known activator of adenylyl cyclase, leading to increased cAMP levels in cells. SDF-2L1 is a protein that can be activated via the cAMP-PKA pathway. Therefore, by increasing cAMP levels, Forskolin can indirectly enhance the functional activity of SDF-2L1. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases (PDEs), enzymes responsible for breaking down cAMP. By inhibiting PDEs, IBMX can increase cellular cAMP levels, indirectly enhancing the activity of SDF-2L1 via the cAMP-PKA pathway. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective PDE4 inhibitor. By inhibiting PDE4, Rolipram increases cAMP levels in cells, indirectly enhancing SDF-2L1 activity via the cAMP-PKA pathway. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2, a prostaglandin, can activate the EP2/EP4 receptors leading to increased adenylyl cyclase activity and elevated cAMP levels. Increased cAMP can enhance the functional activity of SDF-2L1 via the cAMP-PKA pathway. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine activates adrenergic receptors, leading to increased cAMP levels in cells. As SDF-2L1 can be activated by the cAMP-PKA pathway, Epinephrine indirectly enhances the functional activity of SDF-2L1. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a non-selective beta adrenergic agonist, increasing cAMP levels in cells. Increased cAMP enhances the functional activity of SDF-2L1 via the cAMP-PKA pathway. | ||||||
Dobutamine | 34368-04-2 | sc-507555 | 100 mg | $295.00 | ||
Dobutamine is a beta-1 adrenergic receptor agonist that increases cAMP levels in cells. Increased cAMP enhances the functional activity of SDF-2L1 via the cAMP-PKA pathway. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $92.00 $378.00 | 2 | |
Terbutaline is a beta-2 adrenergic receptor agonist, leading to increased cAMP levels in cells. Increased cAMP enhances the functional activity of SDF-2L1 via the cAMP-PKA pathway. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $94.00 $141.00 | ||
Albuterol is a beta-2 adrenergic receptor agonist that boosts cAMP levels in cells. Increased cAMP enhances the functional activity of SDF-2L1 via the cAMP-PKA pathway. | ||||||
NKH 477 | 138605-00-2 | sc-204130 sc-204130A | 5 mg 50 mg | $223.00 $922.00 | 1 | |
NKH477 is a direct adenylyl cyclase activator, leading to increased cAMP levels in cells. Increased cAMP enhances the functional activity of SDF-2L1 via the cAMP-PKA pathway. | ||||||