SDAD1 Activators
SDAD1 Activators encompass a diverse array of chemical compounds that indirectly potentiate the functional activity of SDAD1 through their influence on various signaling pathways. For instance, Forskolin, 8-Bromoadenosine 3',5'-cyclic monophosphate, and Isoproterenol all work by elevating intracellular cAMP levels; this, in turn, activates PKA, which may phosphorylate proteins and substrates that play a role in SDAD1's functional enhancement within its specific signaling context. Similarly, Rolipram sustains PKA activation by inhibiting PDE4, thereby preventing cAMP breakdown. Phorbol 12-myristate 13-acetate is a PKC activator that could modulate SDAD1 activity by influencing the phosphorylation status of proteins within the PKC pathway. LY294002 and U0126, through inhibition of PI3K and MEK1/2 respectively, have the potential to indirectly enhance SDAD1 function by altering other signaling pathways that intersect with the biological processes SDAD1 is involved in.
Additionally, ionophores like Ionomycin and A23187 (Calcimycin) increase intracellularcalcium levels, which activates calcium-dependent kinases and phosphatases, potentially leading to the indirect enhancement of SDAD1 activity through the modulation of associated proteins. Sildenafil, by inhibiting PDE5, raises both cAMP and cGMP levels, which could enhance PKA and PKG activity, thus indirectly promoting SDAD1 activity within their signaling cascades. Epigallocatechin gallate (EGCG), known for its ability to modulate kinase and phosphatase pathways, may also play a role in enhancing SDAD1 activity by altering the phosphorylation states of key proteins. Lastly, the p38 MAPK inhibitor SB203580 could skew cellular signaling towards SDAD1-centric pathways, indirectly enhancing its activity by reducing the competitive influence of the p38 MAPK pathway. Collectively, these SDAD1 Activators, through their targeted effects on multiple and interconnected cellular signaling pathways, contribute to the enhancement of the functional activity of SDAD1 without the need to directly upregulate its expression or act as direct binding activators.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly raises intracellular cAMP levels, which can activate PKA. PKA then phosphorylates specific substrates, potentially enhancing the functional activity of SDAD1 by promoting its proper folding or stability within cellular pathways. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Br-cAMP serves as a cAMP analog that activates PKA. Upon PKA activation, cellular processes linked to the activity of SDAD1 may be positively influenced, thus potentially enhancing SDAD1 function indirectly. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase-4 (PDE4) and prevents the breakdown of cAMP, thus sustaining PKA activation. This could lead to an enhanced functional state of SDAD1 through downstream effects of PKA signaling. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which may activate calcium-dependent kinases and phosphatases that could indirectly increase the activity of SDAD1. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a PKC activator that, by modulating the PKC pathway, might facilitate the functional enhancement of SDAD1 by affecting phosphorylation states of proteins within the same signaling network. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP production, thereby potentially promoting the activity of PKA and subsequently enhancing SDAD1 activity within related signaling pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter the AKT signaling pathway; this modulation might shift the cellular signaling dynamics in a manner that indirectly enhances SDAD1 activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, potentially altering the MAPK/ERK pathway and thereby influencing downstream proteins, which could include enhancement of SDAD1 activity by changing the signaling context in which SDAD1 operates. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that augments intracellular calcium levels, leading to activation of calcium-dependent signaling pathways. This can indirectly enhance the functionality of SDAD1 by modulating associated calcium-sensitive proteins and enzymes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol that has been shown to modulate various signaling pathways, including those involving kinases and phosphatases. This modulation can enhance the activity of SDAD1 by altering the phosphorylation states of proteins within these pathways. | ||||||