SCYL1BP1 Activators
Golgin, RAB6 Interacting proteins are integral to the regulation of Golgi apparatus dynamics and intracellular trafficking. Their activity is modulated by various signaling pathways, making them sensitive to a range of chemical activators that indirectly influence their function. The primary mechanism through which these activators work involves altering intracellular signaling pathways, such as cAMP/PKA, AMPK, PKC, and calcium-dependent pathways. Compounds like Forskolin and Rolipram elevate cAMP levels, either by directly activating adenylate cyclase or inhibiting phosphodiesterases, respectively. This cAMP increase can then activate PKA, which plays a role in modulating Golgi dynamics and potentially influencing Golgin, RAB6 Interacting activity.
Further, compounds like Ionomycin and PMA exert their effects through different mechanisms – Ionomycin by increasing intracellular calcium levels and PMA by activating PKC. These pathways are crucial in cellular trafficking and Golgi function, indirectly affecting Golgin, RAB6 Interacting. Intriguingly, some activators like Brefeldin A and Tunicamycin disrupt normal Golgi function, offering a unique approach to modulate Golgin, RAB6 Interacting activity by altering the cellular environment in which it operates. This diversity in activation mechanisms reflects the complex nature of intracellular signaling and its impact on specific proteins like Golgin, RAB6 Interacting. The interplay between these various signaling molecules and pathways exemplifies the intricate network of cellular communication and regulation, highlighting the potential of these activators in research focused on Golgi apparatus dynamics and associated cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cAMP levels. Elevated cAMP indirectly enhances the activity of Golgin, RAB6 Interacting by modulating the RAB6-mediated Golgi trafficking. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
8-Bromo-cAMP is a cAMP analog that activates PKA. This activation can influence Golgin, RAB6 Interacting activity indirectly through phosphorylation of proteins involved in the RAB6 pathway. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, leading to increased cAMP levels. Higher cAMP may enhance the activity of Golgin, RAB6 Interacting indirectly via PKA-mediated signaling pathways. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which elevates intracellular cAMP levels. This can indirectly influence Golgin, RAB6 Interacting activity through cAMP-dependent pathways. | ||||||
SC514 | 354812-17-2 | sc-205504 sc-205504A | 5 mg 10 mg | $66.00 $89.00 | 13 | |
This compound selectively activates Epac, a guanine nucleotide exchange factor for RAP1. Activated RAP1 can indirectly modulate the function of Golgin, RAB6 Interacting through alterations in cellular trafficking mechanisms. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore, increasing intracellular calcium levels. Elevated calcium may indirectly influence Golgin, RAB6 Interacting by affecting calcium-dependent signaling pathways linked to Golgi function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can indirectly modulate Golgin, RAB6 Interacting activity through PKC-mediated signaling pathways that impact Golgi apparatus dynamics. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR activates AMPK, which can indirectly influence Golgin, RAB6 Interacting through AMPK-related signaling pathways that regulate cellular trafficking and Golgi function. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts Golgi structure and function. It can indirectly modulate Golgin, RAB6 Interacting activity by altering Golgi apparatus dynamics and RAB6-mediated trafficking. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is a sodium ionophore known to disrupt Golgi function. This disruption can indirectly influence Golgin, RAB6 Interacting by affecting intracellular trafficking routes. | ||||||