SCO1 Activators
SCO1 Activators are conceptualized as compounds that can influence the functional activity of SCO1 through modulation of copper homeostasis, an essential element for the function of the SCO1 protein. SCO1, a metallochaperone involved in the incorporation of copper into cytochrome c oxidase, is reliant on a tightly regulated supply of copper ions to fulfill its role in the mitochondrial respiratory chain. Compounds such as Copper(II) sulfate supply the necessary copper ions directly, enhancing the functional activity of SCO1 in the assembly of cytochrome c oxidase. Ascorbic acid plays a supportive role by reducing Cu(II) to Cu(I), the preferred oxidation state of copper for SCO1 interaction, thus increasing the efficiency of SCO1-mediated copper insertion into cytochrome c oxidase.
Other compounds like tetrathiomolybdate, bathocuproine, and clioquinol act as copper chelators or modulators, influencing the distribution and availability of copper within the cell, which can indirectly lead to an enhanced functional state of SCO1 by ensuring a sufficient supply of copper is directed towards mitochondrial processes. Histidine and D-penicillamine may facilitate copper delivery to SCO1, while disulfiram and neocuproine form complexes with copper that might modify the activity or stability of SCO1. Zinc sulfate and manganese(II) chloride provide a competitive interaction with copper ions, which can lead to alterations in copper homeostasis, indirectly enhancing SCO1 activity by affecting the cellular compartmentalization and utilization of copper.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Provides copper ions necessary for SCO1 function in cytochrome c oxidase assembly. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Reduces Cu(II) to Cu(I), enhancing copper availability for SCO1 activity. | ||||||
Ammonium tetrathiomolybdate | 15060-55-6 | sc-239242 sc-239242A sc-239242B sc-239242C | 1 g 10 g 25 g 50 g | $46.00 $199.00 $413.00 $515.00 | ||
Sequesters copper, potentially increasing its bioavailability to SCO1. | ||||||
L-Histidine | 71-00-1 | sc-394101 sc-394101A sc-394101B sc-394101C sc-394101D | 25 g 100 g 250 g 500 g 1 kg | $53.00 $82.00 $185.00 $200.00 $332.00 | 1 | |
Acts as a copper chaperone, potentially delivering copper to SCO1 more efficiently. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Forms complexes with copper, which may alter SCO1 activity indirectly. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $45.00 $94.00 | ||
Chelates copper, potentially enhancing the bioavailability of copper for SCO1. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Competes with copper for binding sites, possibly affecting copper homeostasis for SCO1. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $30.00 | ||
Competes with copper, potentially influencing copper homeostasis and SCO1 activity. | ||||||
Neocuproine | 484-11-7 | sc-257893 sc-257893A sc-257893B sc-257893C sc-257893D | 1 g 5 g 25 g 100 g 250 g | $33.00 $88.00 $291.00 $1086.00 $2341.00 | 1 | |
Chelates copper ions, potentially enhancing copper availability for SCO1. | ||||||
Clioquinol | 130-26-7 | sc-201066 sc-201066A | 1 g 5 g | $44.00 $113.00 | 2 | |
Binds copper and may affect its intracellular distribution, indirectly enhancing SCO1 activity. | ||||||