SCO1 Antibody (D-1): sc-398001

SCO1 Antibody (D-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects SCO1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). SCO1 Antibody (D-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SCO1 protein plays a vital role in mitochondrial function, specifically in the insertion and transport of copper to the active site of cytochrome c oxidase (COX), which is essential for cellular energy production as COX serves as the terminal enzyme in the respiratory chain. Proper functioning of SCO1 is crucial, particularly in tissues with high oxidative phosphorylation demands, such as the brain, heart, and muscle. Deficiencies in SCO1 gene can lead to cytochrome c oxidase deficiency, a heterogeneous disorder that disrupts energy metabolism, while mutations in SCO2 gene can result in a severe condition known as cardioencephalomyopathy with cytochrome c oxidase deficiency, characterized by life-threatening symptoms in infants. Anti-SCO1 antibody (D-1) effectively detects this important protein, making SCO1 (D-1) antibody a valuable tool for researchers studying mitochondrial function and related disorders.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SCO1 Antibody (D-1) References:

1. Cytochrome c oxidase deficiency due to mutations in SCO2, encoding a mitochondrial copper-binding protein, is rescued by copper in human myoblasts.  |  Jaksch, M., et al. 2001. Hum Mol Genet. 10: 3025-35. PMID: 11751685
2. Solution structure of Sco1: a thioredoxin-like protein Involved in cytochrome c oxidase assembly.  |  Balatri, E., et al. 2003. Structure. 11: 1431-43. PMID: 14604533
3. Specific copper transfer from the Cox17 metallochaperone to both Sco1 and Cox11 in the assembly of yeast cytochrome C oxidase.  |  Horng, YC., et al. 2004. J Biol Chem. 279: 35334-40. PMID: 15199057
4. Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase.  |  Leary, SC., et al. 2004. Hum Mol Genet. 13: 1839-48. PMID: 15229189
5. Crystal structure of human SCO1: implications for redox signaling by a mitochondrial cytochrome c oxidase 'assembly' protein.  |  Williams, JC., et al. 2005. J Biol Chem. 280: 15202-11. PMID: 15659396
6. Congenital cataract, muscular hypotonia, developmental delay and sensorineural hearing loss associated with a defect in copper metabolism.  |  Horváth, R., et al. 2005. J Inherit Metab Dis. 28: 479-92. PMID: 15902551
7. Human Sco1 and Sco2 function as copper-binding proteins.  |  Horng, YC., et al. 2005. J Biol Chem. 280: 34113-22. PMID: 16091356
8. Crystal structure of yeast Sco1.  |  Abajian, C. and Rosenzweig, AC. 2006. J Biol Inorg Chem. 11: 459-66. PMID: 16570183
9. A hint for the function of human Sco1 from different structures.  |  Banci, L., et al. 2006. Proc Natl Acad Sci U S A. 103: 8595-600. PMID: 16735468
10. A structural characterization of human SCO2.  |  Banci, L., et al. 2007. Structure. 15: 1132-40. PMID: 17850752
11. A structural-dynamical characterization of human Cox17.  |  Banci, L., et al. 2008. J Biol Chem. 283: 7912-20. PMID: 18093982
12. The Role of COA6 in the Mitochondrial Copper Delivery Pathway to Cytochrome c Oxidase.  |  Swaminathan, AB. and Gohil, VM. 2022. Biomolecules. 12: PMID: 35053273

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SCO1 Antibody (D-1) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-SCO1 Antibody (D-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SCO1 Antibody (D-1) Specifications

Alternate Product Name: SCO1

Product Clone Name: D-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 183-210

Epitope Target: SCO1

Epitope Species: human

Product Reactivity/Detection: SCO1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for SCO1 Antibody (D-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin